{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:58:43Z","timestamp":1755226723780,"version":"3.43.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Neurol"],"abstract":"<jats:p>Introduction: High levels of lipoprotein (a) [Lp (a)] have gained attention as a risk factor for venous thrombosis. Venous thrombosis during pregnancy in women without thrombophilic predisposition is attributed to pregnancy itself. Herein, we report a case of high Lp (a) levels manifesting as recurrent deep vein thrombosis (DVT) and cerebral venous sinus thrombosis (CVST) in different pregnancies. Case Presentation: A 29-year-old Nepalese woman developed DVT during her first pregnancy. Examination revealed no thrombophilic predisposition. The thrombus resolved with oral anticoagulant medication, which was discontinued after 3 months. During the second pregnancy, prophylactic subcutaneous heparin injections were initiated to prevent venous embolism. Following several days of non-administration of heparin, she experienced left occipital pain, and magnetic resonance venogram showed left CVST. Oral anticoagulants were initiated, and her headache resolved within a few days. Additional blood tests showed abnormally high levels of Lp (a) at 113 mg\/dL. Six months later, the CVST was partially recanalized. Conclusion: If venous thrombosis develops during pregnancy in patients without thrombophilic predisposition, Lp (a) levels should be monitored, and long-term anticoagulant medication may be desirable in those with high Lp (a) levels to prevent recurrence of venous thrombosis. <\/jats:p>","DOI":"10.1159\/000546461","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T16:00:46Z","timestamp":1752508846000},"page":"107-112","source":"Crossref","is-referenced-by-count":0,"title":["High Lipoprotein (a) Levels Causing Recurrent Deep Vein Thrombosis and Cerebral Venous Sinus Thrombosis in Different Pregnancies: A Case Report"],"prefix":"10.1159","volume":"17","author":[{"given":"Akihiro","family":"Okada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kawauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Terada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/ATV.0000000000000147"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.01.029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90181-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/25166085211046147"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000502454"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1310-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.08.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28030969"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008951"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000001043"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2012.09.009"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.07.015"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.7.743"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-018-1769-0"}],"container-title":["Case Reports in Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T16:03:16Z","timestamp":1755014596000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546461","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29545145","asserted-by":"subject"}]},"ISSN":["1662-680X"],"issn-type":[{"type":"electronic","value":"1662-680X"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}