{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:30:18Z","timestamp":1789695018921,"version":"4.0.1"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"abstract":"<jats:p>Introduction: Craniopharyngioma (CP), Rathke Cleft Cyst (RCC) and Empty Sella (ES) are clinical conditions that may lead to endocrine disorders.\nMethods: Clinical data of all pediatric patients aged 0-18 years with diagnosis of CP, RCC or ES, referred to our department over the period 2000-2024 were analysed.\nResults: Data of 13 subjects with CP, 35 subjects with RCC and 32 patients with ES were analysed. Mean age at diagnosis was 6.6 \u00b1 1.2 years in the CP group, 8.45 \u00b1 3.2 years in the RCC group, and 10.55 \u00b1 2.1 years in the ES group (p = 0.03). \nPrior endocrine disorder was the reason for requesting MRI in 27\/80 patients: 1\/13 of patients with CP, 16\/35 of those with RCC, and 10\/32 of patients with ES (p = 0.04).\nAmong RCC patients, higher age and RCC size were observed in subjects with endocrine disorders  (p = 0.04). Similar trend was observed in patients with ES, with significantly higher age in those with endocrine disorders compared to those without (p = 0.04). \nDuring follow-up, endocrine disorders were diagnosed in all patients with CP (13\/13; 100%), in 5 out of 20 patients with RCC (25%), and in none of the patients with ES.\nConclusion: CP, RCC and ES need baseline and over a prolonged period of time endocrinological and neuroradiological follow-up, in order to detect promptly endocrine defects and sellar\/suprasellar region alterations and multidisciplinary follow-up in tertiary centres is mandatory.<\/jats:p>","DOI":"10.1159\/000546493","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T16:01:56Z","timestamp":1747670516000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["\u201cCraniopharyngioma (CP), Rathke cleft cyst (RCC) and empty sella (ES) natural history and endocrine outcome in pediatric age: a single tertiary centre experience over the 2000-2024 period\u201d"],"prefix":"10.1159","author":[{"given":"Gerdi","family":"Tuli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Munarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,19]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T16:01:56Z","timestamp":1747670516000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000546493","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]}}}