{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:10:28Z","timestamp":1782753028456,"version":"3.54.5"},"reference-count":15,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"abstract":"<jats:p>&lt;p&gt;Introduction: The gold-standard treatment of otosclerosis is stapedectomy. Recent surgical advancements have led to the use of two approaches for stapedectomy: CO&lt;sub&gt;2&lt;\/sub&gt; laser and microdrill-assisted stapedotomy. There is limited data on the comparison of both interventions. This study aims to provide an update on evidence-based medicine on the use of CO&lt;sub&gt;2&lt;\/sub&gt; laser and microdrill in stapedotomy. Methods: A systematic review and meta-analysis were conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Guidelines and an electronic search was conducted to identify studies comparing CO&lt;sub&gt;2&lt;\/sub&gt; laser versus microdrill for stapedectomy. Post-operative hearing outcomes and the rates of sensorineural hearing loss (SNHL) were identified as primary outcomes. Secondary outcomes included post-operative complications such as vertigo and abnormal taste sensation. The analysis was based on fixed or random-effects modelling. Results: Four studies enrolling 1,540 patients were identified. Post-operative hearing outcomes (odds ratio [OR] = 1.23, p = 0.1), SNHL (OR = 0.8, p = 0.74), and abnormal taste sensation post-operatively (OR = 0.84, p = 0.58) were not significantly different between both interventions. However, a significant difference was found between both groups for post-operative vertigo, showing a higher rate for the microdrill group (OR = 2.54, p = 0.02). Conclusion: In conclusion, CO&lt;sub&gt;2&lt;\/sub&gt; laser and microdrill are both effective procedures for stapedectomy, as they both produced comparable outcomes in post-operative hearing outcomes and SNHL. However, microdrill had higher rates of post-operative vertigo, possibly indicating that the CO&lt;sub&gt;2&lt;\/sub&gt; laser is a slightly more preferable option. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000546504","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T12:01:55Z","timestamp":1747915315000},"page":"133-142","source":"Crossref","is-referenced-by-count":1,"title":["Comparing CO\n                    <sub>2<\/sub>\n                    Laser and Microdrill in Primary Stapedotomy: A Systematic Review and Meta-Analysis of Post-Operative Hearing Outcomes and Complications"],"prefix":"10.1159","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-9824","authenticated-orcid":false,"given":"Eyad","family":"Jamileh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuha","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Gire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmalik","family":"Alsaif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohannad","family":"Jamileh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Xamza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0194-5998(95)70103-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2013.12.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215115001280"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000439177"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1217562"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07739-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-021-06926-y.8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05415-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1792086"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181b76b08"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.06.105"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06117-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24514"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1801315"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181a52ab4"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:02:19Z","timestamp":1761321739000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":15,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2025,10,24]]},"published-print":{"date-parts":[[2025,10,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000546504","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29110049","asserted-by":"subject"}]},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}