{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:00:55Z","timestamp":1774584055291,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflamm Intest Dis"],"abstract":"<jats:p>Background: Ciclosporin and infliximab have equal short-term efficacy in treating acute severe ulcerative colitis (ASUC). However, data about long-term outcome and switching to a second rescue therapy are limited. Methods: Patients with steroid-refractory ASUC treated at a tertiary center in Switzerland were retrospectively analyzed regarding the outcome of different rescue therapies. Colectomy-free survival rates at 1, 3, and 5 years were estimated through Kaplan-Meier method. Furthermore, predictors of colectomy, the presence of adverse events at 1 year and mortality during the entire follow-up were assessed. Results: We analyzed a total of 46 patients who were treated initially with either ciclosporin (n = 31) or infliximab (n = 15) due to steroid-refractory ASUC between January 2010 and July 2021. A total of 13% patients received a second rescue therapy. In sum, 78%, 67%, and 48% were colectomy-free at 1, 3, and 5 years, respectively. Although there was a significant difference between the three arms in colectomy-free survival (p = 0.026), a post hoc analysis could not demonstrate a difference between each individual therapy compared to another. The post hoc analysis indicated a nonsignificant benefit with sequential therapy in comparison to ciclosporin (CsA) regarding the colectomy-free survival (p = 0.087). The outcome between infliximab and CsA was not statistically different (p = 0.149). The number of previous advanced therapies was negatively associated with 1-year colectomy-free survival (p = 0.049). Other variables such as age at hospitalization, sex, dose of steroids, disease duration, and albumin did not correlate with a higher risk of 1-year colectomy. Conclusions: This real-world single-center analysis confirms the equal efficacy and safety of infliximab and ciclosporin over a follow-up of 5 years. Patients not responding to the first may benefit of a second rescue therapy without increasing the risk of complication or mortality. <\/jats:p>","DOI":"10.1159\/000546511","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T16:01:57Z","timestamp":1748275317000},"page":"155-160","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Outcome of Ciclosporin and Infliximab as Rescue Therapy in Steroid-Refractory Acute Severe Ulcerative Colitis"],"prefix":"10.1159","volume":"10","author":[{"given":"Florian","family":"Grob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"H\u00e4berling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Novacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3564-639X","authenticated-orcid":false,"given":"Andrea","family":"Kreienb\u00fchl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-4125","authenticated-orcid":false,"given":"Luc","family":"Biedermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-9188","authenticated-orcid":false,"given":"Gerhard","family":"Rogler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz032"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000452459"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12375"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06958.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab177"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12122039"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620977405"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000350"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30003-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61084-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.05.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091339"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4947.1041"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(74)90552-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.09.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2021.0584"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313060"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15592"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.033"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000152"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx009"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.05.038"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.11.022"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"}],"container-title":["Inflammatory Intestinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T16:02:20Z","timestamp":1750867340000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546511","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29148407","asserted-by":"subject"}]},"ISSN":["2296-9403","2296-9365"],"issn-type":[{"value":"2296-9403","type":"print"},{"value":"2296-9365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}