{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:21:08Z","timestamp":1755224468981,"version":"3.43.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"abstract":"<jats:p>Introduction: There is a lack of sufficient evidence-based data to support personalized treatment decisions for Zenker\u2019s diverticulum. This study evaluates not only short-term outcomes of different treatment approaches but also identifies prognostic factors for long-term recurrence-free survival and quality of life. Methods: We retrospectively analyzed all patients diagnosed with Zenker\u2019s diverticulum at our center between 2001 and 2021. Long-term follow-up data, including validated quality-of-life scores (EAT-10 and GIQLI), were evaluated. Results: Overall, 97 patients underwent open surgery (OS), 37 received endoscopic surgery (ES), and 17 patients were treated conservatively. Treatment-related morbidity was 25% for OS, 5% for ES, and nil for conservative management (p = 0.004). After a median follow-up of 107 months, patients treated with OS or ES experienced less dysphagia (p &lt; 0.001) and regurgitation (p &lt; 0.001) compared to initial presentation. ES patients had a more favorable quality-of-life score than those treated conservatively (GIQLI: 125 vs. 106; p = 0.010 but not EAT-10: 2 vs. 6; p = 0.207). Recurrence rates were 28% for OS, 62% for ES, and 65% for conservative treatment (p &lt; 0.001). OS was identified as an independent prognostic factor for improved recurrence-free survival. Conclusion: Despite higher short-term morbidity, OS was associated with the best recurrence-free survival. Long-term symptoms and quality-of-life outcomes were favorable and comparable between OS and ES. <\/jats:p>","DOI":"10.1159\/000546619","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T12:02:08Z","timestamp":1749211328000},"page":"174-184","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Outcomes of Zenker\u2019s Diverticula Treatment: Invasive Procedures Ensure Sustained Quality of Life despite Higher Short-Term 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