{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:49:00Z","timestamp":1779893340029,"version":"3.53.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>&lt;p&gt;Introduction: A Zenker diverticulum (ZD) is a sac-like outpouching at the pharyngo-oesophageal junction, which is characterised by dysphagia and regurgitation. Surgery has been the predominant treatment but carries the burden of invasiveness, complications, and recurrence. Zenker peroral endoscopic myotomy (Z-POEM) is an alternative minimally invasive endoscopic treatment for ZD. We report on the safety and efficacy of Z-POEM in the UK. Methods: Consecutive patients undergoing Z-POEM by expert interventional endoscopists at four UK referral centres were retrospectively analysed between 2019 and 2024. Patient demographics, technical and clinical success, and 30-day adverse events were recorded. The primary outcome was clinical success, which was defined as a reduction in Dakkak and Bennett dysphagia score to \u22641 without need for repeat intervention. Results: Among 61 patients undergoing Z-POEM, the median age was 76 (IQR 69\u201380), 37.7% (n = 23) were female, mean pouch size was 37.3 mm (SD 18.0) in depth, and 37.3% had undergone prior intervention. The overall technical success was 100%, mean procedural time was 49.4 min (SD 19.3), and 10 patients underwent a hybrid procedure due to submucosal fibrosis. Overall, the clinical success was 93.1% over a mean follow-up of 11.2 months. There were five AEs related to the procedure classified as AGREE grade II (8.5%), and the recurrence rate was 11.1% over a median time of 7.5 months (IQR 6.3\u201310.3). Conclusion: Z-POEM is a safe and effective endoscopic treatment for ZD that is associated with high technical and clinical success. A hybrid procedure may be utilised in the presence of submucosal fibrosis. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000546645","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T12:04:21Z","timestamp":1751285061000},"page":"477-487","source":"Crossref","is-referenced-by-count":2,"title":["Zenker Peroral Endoscopic Myotomy Is Safe and Effective for the Management of Pharyngeal Pouch: A Multicentre Retrospective Cohort Study"],"prefix":"10.1159","volume":"43","author":[{"given":"Benjamin","family":"Norton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Siggens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-4973","authenticated-orcid":false,"given":"Apostolis","family":"Papaefthymiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Telese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Duku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Murino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borzoueh","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muntzer","family":"Mughal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf","family":"Bisschops","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Birchall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan","family":"Haidry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.910.506"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/den.13035"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.01.039"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.318"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-105574"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.11.038"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000351433"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-022-09021-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/a-2067-9105"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doaa019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/a-1518-7223"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-11164-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001356"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2023.103864"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020187"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-020-00809-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.07.034"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325579"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2023.06.017"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1055\/a-1481-7728"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2024.0902"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-10512-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001977"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:03:10Z","timestamp":1759420990000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10,2]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546645","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}