{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T11:29:34Z","timestamp":1785583774296,"version":"3.56.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Introduction: Herpetic whitlow, due to herpes simplex virus (HSV) type 1 or 2, typically presents with vesicles that may coalesce into bullae. Herpetic whitlow often resolves without intervention but can be treated with antiviral medications. Case Presentation: Herein is a report of a 68-year-old female patient with a history of well-controlled human immunodeficiency virus (HIV) infection and a 4-year history of recurrent HSV-2 herpes genitalis who failed multiple trials of standard antiviral therapy clinically confirming a case of resistant HSV-2 infection, with recurrent tender lesions on her digits. Physical examination showed bullae involving the nail folds of her right thumb and left index finger. Initial PCR was negative for HSV-1 and HSV-2, but repeat PCR was positive for HSV-2. Treatment with foscarnet resulted in clinical improvement of both herpetic whitlow and herpes genitalis. Conclusion: Though herpetic whitlow typically resolves without intervention, a case is described of recurrent lesions in an HIV-positive patient unresponsive to multiple first-line antiviral treatment regimens and an interdisciplinary approach to treatment in a challenging case. <\/jats:p>","DOI":"10.1159\/000546664","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T16:01:55Z","timestamp":1748534515000},"page":"224-230","source":"Crossref","is-referenced-by-count":2,"title":["Management of Resistant Herpetic Whitlow: A Case of Recurrent Herpetic Whitlow Resistant to Standard Therapy"],"prefix":"10.1159","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0436","authenticated-orcid":false,"given":"Amit","family":"Singal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Ting","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-9304","authenticated-orcid":false,"given":"Shari R.","family":"Lipner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.08.017"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.10.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.hansur.2022.11.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-9-710"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0000000000001187"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(59)90804-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.08.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.012"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.16.1.114-128.2003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.19592037.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-010207"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T16:02:27Z","timestamp":1750780947000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546664","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29163716","asserted-by":"subject"}]},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]}}}