{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:55:28Z","timestamp":1775753728926,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Objectives: This study investigates the impact of reduced gonadotropin doses during controlled ovarian hyperstimulation (COH) on progesterone levels in the late follicular phase of IVF\/ICSI-ET. Design: This was a retrospective cohort study employing propensity score matching to balance groups. Participants\/Materials: This study enrolled infertile patients undergoing IVF\/ICSI-ET at the Reproductive Medicine Center of the 900th Hospital from January 2017 to July 2020. Setting: This study was carried out at the Reproductive Medicine Center, 900th Hospital of PLA Joint Logistic Support Force, formerly Fuzhou General Hospital. Methods: A total of 1,380 patients were enrolled; 670 received reduced gonadotropin doses (12.5\u201375 units\/day from days 6 to 8), and 710 underwent routine treatment. The primary outcome measured was progesterone levels on trigger day. Results: Progesterone levels on trigger day were significantly lower in the gonadotropin dose reduction group (1.24 \u00b1 0.51) compared to the control group (1.34 \u00b1 0.53, p &lt; 0.001). The proportion of patients with P \u22651.5 ng\/mL was significantly lower in the gonadotropin dose reduction group compared to the control group (22.7% vs. 29.9%, p = 0.003). Multivariable logistic regression indicated that dose reduction decreased the risk of progesterone elevation (OR = 0.535, 95% CI: 0.404\u20130.709). Limitations: The study is limited by its retrospective design, which may introduce biases. Conclusions: Reducing gonadotropin doses during COH may lower elevated progesterone levels in the late follicular phase, potentially improving embryo outcomes in IVF\/ICSI-ET.<\/jats:p>","DOI":"10.1159\/000546691","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T12:02:33Z","timestamp":1750766553000},"page":"180-185","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Gonadotropin Dose Reduction during Controlled Ovarian Hyperstimulation on Progesterone Levels and Embryo Outcomes in Women Undergoing IVF\/ICSI-ET with GnRH-A Protocol"],"prefix":"10.1159","volume":"91","author":[{"given":"Hongmei","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wujian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.02.128"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der126"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.04.041"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.12.016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd006919.pub4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd001750.pub4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.11.047"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.049"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.4.933"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.jhrs_162_22"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1727879"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0715-6"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew213"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.02.132"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11247300"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05342-w"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00067"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der324"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.02.025"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.661707"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546691","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:01:02Z","timestamp":1775750462000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,9]]},"published-print":{"date-parts":[[2026,4,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000546691","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29254634","asserted-by":"subject"}]},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}