{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:57:38Z","timestamp":1784037458904,"version":"3.55.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"abstract":"Introduction: The aim of the study was to evaluate the effect of modified posterior scleral reinforcement (PSR) surgery integrated with comprehensive amblyopia rehabilitation in children with high myopia-related anisometropic amblyopia. Methods: A retrospective cohort analysis was conducted, including 24 eyes treated with the modified PSR intervention and 20 nonsurgical controls. Baseline and 3-year postoperative assessments included best-corrected visual acuity (BCVA), cycloplegic spherical equivalent (SE), and axial length (AL). Results: At the 3-year follow-up, the PSR cohort exhibited significant BCVA enhancement (p < 0.001) alongside suppressed myopic progression, as evidenced by reduced SE deterioration (p < 0.001) and AL elongation (p < 0.001), compared to controls. Amblyopia treatment success rates were markedly higher in the surgical group (p < 0.001). Stratified analyses revealed greater BCVA gains in the PSR group across all amblyopia severities, with pronounced improvements in severe amblyopia cases. Age-specific outcomes demonstrated attenuated AL growth in both preschoolers (<6 years, p < 0.01) and school-aged children (\u22656 years, p < 0.05). Notably, younger preschoolers in the PSR group achieved superior BCVA gains (p < 0.05), whereas older controls showed limited responsiveness. Conclusion: The combination of modified PSR surgery and multidisciplinary amblyopia rehabilitation represents a promising therapeutic approach for mitigating refractive error progression and enhancing visual outcomes in children with high myopia-associated anisometropic amblyopia. <\/jats:p>","DOI":"10.1159\/000546921","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T12:07:10Z","timestamp":1751285230000},"page":"381-388","source":"Crossref","is-referenced-by-count":1,"title":["Management of Anisometropic Amblyopia Associated with Unilateral High Myopia in Children with Modified Posterior Scleral Reinforcement"],"prefix":"10.1159","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-1436","authenticated-orcid":false,"given":"Minshu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuran","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.12.014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23707"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-04212-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000570"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-024-02929-w"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67078-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0000000000010792"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.08.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(72)90544-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-2963-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000441900"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.035"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.4.437"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113627"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(01)01024-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.10.008"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(14)74278-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.030"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archopthalmol.2011.1203"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(78)90121-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s224463"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.179"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T16:01:00Z","timestamp":1754496060000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546921","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}