{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:15:33Z","timestamp":1774635333736,"version":"3.50.1"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"abstract":"<jats:p>Background: \nType 1 diabetes mellitus (T1D) is an autoimmune disease marked by the destruction of pancreatic \u03b2cells,\nnecessitating lifelong management. Current therapies, such as insulin injections and pancreas \ntransplants, are effective but impose significant burdens, driving the need for innovative solutions. \nAmong these, the bioartificial pancreas (BAP) stands out as a promising approach. By integrating living \ninsulin-producing cells with synthetic matrices, BAP technology aims to replicate natural pancreatic \nfunction, offering the potential for more physiologically relevant and patient-friendly treatment.\nSummary:\nThis review highlights recent advancements in BAP technology, emphasizing innovations in design, \nmaterials, and encapsulation techniques that enhance cell viability and function. Key developments \ninclude the use of biocompatible materials for cell encapsulation, continuous glucose monitoring \nsystems, and closed-loop control algorithms, which collectively enable real-time glucose regulation. \nThese breakthroughs address critical challenges such as immune rejection and suboptimal device \nperformance, paving the way for clinical translation.\nKey Messages: \nBAP technology represents a paradigm shift in T1D treatment, with the potential to alleviate the daily \nburdens of insulin management. However, challenges remain, including improving device longevity, \nbolstering immune protection, and reducing production costs to ensure broader accessibility. Future \nadvancements may emerge from integrating BAP systems with cell-protective therapies, further \nenhancing their efficacy. While hurdles persist, the BAP signifies a transformative step toward \nsimplifying diabetes management and improving the quality of life for millions worldwide<\/jats:p>","DOI":"10.1159\/000546926","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T16:02:22Z","timestamp":1749744142000},"page":"1-22","source":"Crossref","is-referenced-by-count":2,"title":["The Future of Diabetes Care: Exploring the Potential of Bioartificial Pancreas and DIY APS Innovations"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7132-3183","authenticated-orcid":false,"given":"Aagash","family":"Nedunchezhian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-6477","authenticated-orcid":false,"given":"Archana","family":"Rajavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramya Lakshmi","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-4604","authenticated-orcid":false,"given":"Prakash","family":"Gangadaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Natesan Sella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,6,11]]},"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T16:02:22Z","timestamp":1749744142000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000546926","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"value":"1015-2008","type":"print"},{"value":"1423-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,11]]}}}