{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:08:05Z","timestamp":1764608885695,"version":"3.46.0"},"reference-count":50,"publisher":"S. Karger AG","issue":"11","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"<jats:p>Introduction: All dialysis modalities can potentially improve physical activity levels and patient well-being, primarily through better toxin clearance. We sought to assess the impact of medium cut-off hemodialysis (MCO-HD), high-flux hemodialysis (HF-HD), and high-flux hemodiafiltration (HF-HDF) on quantitative physical performance measures, which are prognostic for quality of life and mortality risk. Methods: Ten maintenance hemodialysis patients received MCO-HD, HF-HD, and HF-HDF, each for a duration of 6 months. Outcomes encompassed alterations in physical activity levels, assessed with the International Physical Activity Questionnaire, and physical performance, evaluated through the 5-times sit-to-stand, 4-meter gait speed, grip strength tests, and bioelectrical impedance analysis. Results: The cohort comprised 7 men and 3 women with a median dialysis vintage of 96 months (IQR: 36). Dialysis adequacy (single-pool KtV \u22651.2) was attained across all modalities for 18 months, with no notable alterations in nutritional and inflammation markers, including serum albumin. Self-reported physical activity improved during MCO-HD (total MET min\/week 234.5 [IQR: 1,188] vs. 1,229.5 [IQR: 1,683], p = 0.019). There were no significant changes in handgrip strength, gait speed, or muscle mass in either group, nor were there any notable differences between the groups. The 5-times sit-to-stand test has shown stability in the MCO-HD group, whereas a substantial enhancement over 6 months observed with the HF-HDF (12.34 [IQR: 3.88] vs. 10.18 [IQR: 3.14] seconds, p = 0.022]). Conclusion: The MCO-HD group reported elevated physical activity levels, while the HF-HDF group demonstrated considerable enhancement in low extremity strength. The patient-centered selection of dialysis modality, including the implementation of exercises and nutritional interventions, may improve physical performance and patient outcomes.<\/jats:p>","DOI":"10.1159\/000546941","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T16:00:40Z","timestamp":1752508840000},"page":"652-661","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Physical Function in Hemodialysis Patients Treated with Medium Cut-Off Dialyzers, High-Flux Dialyzers, and Hemodiafiltration"],"prefix":"10.1159","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-3010","authenticated-orcid":false,"given":"Gizem","family":"Kumru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busra","family":"Haktaniyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Ates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-318X","authenticated-orcid":false,"given":"Sehsuvar","family":"Erturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Nergizoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Keven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sule","family":"Sengul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sim","family":"Kutlay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08410814"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07050521"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030378"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000494016"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq138"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.01.024"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12056"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02407-w"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000355798"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000485729"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm022"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15090531"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169024"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-023-01771-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.01.013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000508803"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000381255"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy209"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs407"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304820"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.07.014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/20543581211067087"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100431"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab202"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V451205"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0084-2"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2015.04.006"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr051"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2009.10.030"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.465"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2466\/06.08.PMS.111.4.278-284"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00288"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz189"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1159\/000508061"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1159\/000499759"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx191"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02562-3"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64622-z"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13425"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae232"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.44"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf024"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.818921"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00317.2018"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa173"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.04.009"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-024-02049-9"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:03:25Z","timestamp":1764608605000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,12,1]]},"published-print":{"date-parts":[[2025,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000546941","archive":["Portico"],"relation":{},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"type":"print","value":"0253-5068"},{"type":"electronic","value":"1421-9735"}],"subject":[],"published":{"date-parts":[[2025,7,14]]}}}