{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:33:15Z","timestamp":1754145195971,"version":"3.41.2"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: Giant cell tumors of bone (GCTBs) are locally aggressive tumors that can induce pathological fractures. Previous reports suggest that denosumab induces intratumoral ossification in \u03b2-catenin positive GCTB. However, its effect on the complete resection of GCTB with extraskeletal lesions remains unclear. Case Presentation: A 45-year-old woman with a pathological fracture of the left distal femur was diagnosed with GCTB based on the biopsy findings, which revealed both H3.3 G34W and nuclear \u03b2-catenin positivity. Eight courses of neoadjuvant denosumab therapy were administered to visualize the extraskeletal lesions; subsequently, en bloc resection with megaprosthetic reconstruction was successfully performed. Pathological examination revealed intratumoral ossification without osteoclastic giant cells. Two years after the surgery, no evidence of local recurrence was recorded. Conclusion: Neoadjuvant denosumab therapy is an effective approach for managing \u03b2-catenin positive GCTB with pathological fractures as it promotes intratumoral ossification and facilitates complete resection of GCTB, including extraskeletal lesions. <\/jats:p>","DOI":"10.1159\/000546985","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:02:30Z","timestamp":1750075350000},"page":"972-978","source":"Crossref","is-referenced-by-count":0,"title":["Beta-Catenin Positive Giant Cell Tumor of Bone with Pathological Fracture Treated with Neoadjuvant Denosumab Therapy for Visualizing Extraskeletal Lesions"],"prefix":"10.1159","volume":"18","author":[{"given":"Itaru","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-8236","authenticated-orcid":false,"given":"Yoichi","family":"Kaneuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-0795","authenticated-orcid":false,"given":"Michiyuki","family":"Hakozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Nikaido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01047-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.01.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.580605"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2546-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.02.011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2019.11.3.352"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e31805d85e4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-1157"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-017-3664-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4634-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17728-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-330"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.100B12.BJJ-2018-0189.R2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1459-6"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000546985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T16:02:36Z","timestamp":1752681756000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000546985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000546985","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29325713","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,6,16]]}}}