{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:20:07Z","timestamp":1783956007663,"version":"3.55.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflamm Intest Dis"],"abstract":"<jats:p>&lt;p&gt;Introduction: It is crucial to predict the effectiveness of advanced therapies before their administration in ulcerative colitis (UC). Only a few studies have revealed predictive histological factors. Here, we sought to determine whether conventional histology of pretreatment endoscopic biopsy specimens can predict the response to integrin inhibitors. Methods: In the present single-center retrospective study, we examined histopathological findings before initiating an integrin inhibitor. Primary response (PR) was defined as a \u22653-point decrease in the partial Mayo score at 14 weeks. Logistic regression was used to identify the factors predictive for a PR. Results: We analyzed 21 biological and Janus kinase inhibitor-na\u00efve patients with UC. The median baseline Mayo score was 7 (IQR, 6\u20138), and the C-reactive protein was 0.36 (IQR, 0.11\u20130.74). Histological findings included large lymphoid follicles (LF) in 61.9% (13\/21), basal plasma cell infiltration in 52.4% (11\/21), and eosinophilic infiltration (EO) in 42.9% (9\/21). PR at 14 weeks was achieved in 57.1% (12\/21). Among PR patients, LF was present in 91.7% (11\/12), BP in 41.7% (5\/12), and EO in 25.0% (3\/12). PR was observed in 76.9% (10\/13) of LF-positive patients vs. 12.5% (1\/8) of LF-negative patients (p = 0.01). LF was significantly associated with the response to integrin inhibitors, whereas BP and EO were not. Conclusion: The presence of LF in biopsy specimens predicts the response to integrin inhibitors in patients with UC. Conventional histological examinations may aid in predicting therapeutic responses to advanced therapies. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000547013","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:14:23Z","timestamp":1765358063000},"page":"224-232","source":"Crossref","is-referenced-by-count":1,"title":["Histological Predictors for Therapeutic Response to Integrin Inhibitors in Patients with Ulcerative Colitis"],"prefix":"10.1159","volume":"10","author":[{"given":"Takuya","family":"Kimizuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-7660","authenticated-orcid":false,"given":"Katsuyoshi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-3536","authenticated-orcid":false,"given":"Tadakazu","family":"Hisamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Hibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.04.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.02.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96019-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.06.008"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-022-04176-w"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otad059"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.20912"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.80383"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz251"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181e751df"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47618-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1439-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw154"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.153973"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12725"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05628-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144141"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0415-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001039"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.02.016"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000561"}],"container-title":["Inflammatory Intestinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:14:25Z","timestamp":1765358065000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547013","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29649476","asserted-by":"subject"}]},"ISSN":["2296-9403","2296-9365"],"issn-type":[{"value":"2296-9403","type":"print"},{"value":"2296-9365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]}}}