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Over the past 2 decades, however, the treatment paradigm has markedly shifted. Summary: The introduction of tyrosine kinase inhibitors (TKIs), such as imatinib, dasatinib, and ponatinib, has revolutionized frontline therapy, significantly improving remission rates and long-term survival. These agents, when combined with reduced-intensity chemotherapy or even with corticosteroids, have enabled less toxic regimens, particularly beneficial for older or unfit patients. The implementation of measurable residual disease monitoring has emerged as a pivotal tool for risk stratification and therapeutic decision-making. Consequently, the role of allogeneic hematopoietic stem cell transplantation, considered a cornerstone of curative treatment, is being reevaluated in patients achieving sustained deep molecular responses. More recently, immunotherapeutic strategies \u2013 including the bispecific T-cell engager blinatumomab and chimeric antigen receptor (CAR) T-cell therapies \u2013 have emerged as effective alternatives to conventional chemotherapy and TKIs. Key Messages: While TKIs remain the backbone of treatment, the integration of immunotherapeutic strategies \u2013 including bispecific antibodies and CAR T-cell therapy \u2013 has expanded therapeutic options, not only in the R\/R setting but increasingly in frontline regimens. Ongoing research aimed at optimizing the sequencing, combination, and duration of these therapies is essential to further enhance clinical outcomes.<\/jats:p>","DOI":"10.1159\/000547026","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T12:02:30Z","timestamp":1750766550000},"page":"24-38","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of Philadelphia-Positive Acute Lymphoblastic Leukemia"],"prefix":"10.1159","volume":"149","author":[{"given":"Anna","family":"Torrent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-6024","authenticated-orcid":false,"given":"Josep 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