{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:15:18Z","timestamp":1777486518675,"version":"3.51.4"},"reference-count":29,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Allergic sensitization varies by region and environmental conditions. Given Peru\u2019s diverse climatic conditions, this study aimed to assess the relationship between climate variability and IgE-mediated sensitization patterns in four Peruvian cities. Methods: Patients aged 3 to 70 years diagnosed with allergic rhinitis and\/or asthma were recruited in Piura, Lima, Tarapoto, and Arequipa. Cities were classified using the Thornthwaite methodology adopted by SENAMHI. IgE-mediated sensitization was evaluated through skin prick tests and the Allergy Explorer 2 assay to detect reactivity to molecular allergen components. Chi-square analysis and Tukey\u2019s multiple comparisons identified significant differences among climatic zones. Results: Allergic sensitization patterns varied across climate regions. In temperate arid zones, Blo t 5 sensitization was higher (25.3%) compared to warm arid zones (6.3%, p = 0.050). Fel d 1 sensitization showed marked regional differences (56.0% in temperate arid vs. 18.4% in warm rainy zones, p = 0.003). Despite having the highest humidity (92.3%), Tarapoto showed lower sensitization rates across all molecular components for mites in comparison with cities that are also characterized by high humidity, with most differences reaching statistical significance (p &lt; 0.001). Pet allergen sensitization demonstrated climate-dependent variations, with both Fel d 1 and Can f 1 showing higher rates in temperate arid zones. Conclusion: Peru\u2019s climatic diversity could be associated with distinct allergic IgE-mediated sensitization patterns, highlighting environmental factors\u2019 relevance in allergic disease management. Lower mite sensitization in the highest humidity zone suggests factors beyond humidity influence regional allergen sensitization patterns.<\/jats:p>","DOI":"10.1159\/000547036","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T12:05:45Z","timestamp":1751285145000},"page":"261-272","source":"Crossref","is-referenced-by-count":2,"title":["Patterns of Immunoglobulin E-Mediated Molecule Sensitization across Four Peruvian Cities: Exploring Relationships with Regional Climate Classifications"],"prefix":"10.1159","volume":"187","author":[{"given":"C\u00e9sar 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