{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:56:04Z","timestamp":1787241364485,"version":"build-2736575974"},"reference-count":295,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"abstract":"<jats:p>Background: Genetic diseases collectively affect more than 300 million individuals worldwide, posing a significant health burden, as diagnosis is often challenging and therapeutic options are limited. Recent genetic technological advancements are improving the management of many inherited disorders, including genetic kidney disorders (GKDs), the leading cause of early-onset chronic kidney disease (CKD) and the cause of 10\u201315% of kidney replacement therapy in adults. Summary: GKDs fall into different clinical categories, including cystic and fibro-cystic diseases in the setting of ciliopathies, rare conditions caused by the dysfunction of the primary cilium, typically characterized by multiorgan dysfunction. CKD is a significant cause of morbidity and mortality in these patients and a correct diagnosis is crucial for patient\u2019s management. Key Message: The present review analyzes whether advances in genomic technologies have provided benefit in the ciliopathy field, in both modeling renal diseases and improving patient\u2019s care.<\/jats:p>","DOI":"10.1159\/000547131","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:02:33Z","timestamp":1750939353000},"page":"545-563","source":"Crossref","is-referenced-by-count":1,"title":["Genome-Based Advances in Modeling Renal Ciliopathies and Enhancing Patient Care"],"prefix":"10.1159","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-0837","authenticated-orcid":false,"given":"Floriana","family":"Secondulfo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Del Vecchio Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-3826","authenticated-orcid":false,"given":"Giovanna","family":"Capolongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Piluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Nigro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-9392","authenticated-orcid":false,"given":"Alessandra F.","family":"Perna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-8614","authenticated-orcid":false,"given":"Giovambattista","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-2783","authenticated-orcid":false,"given":"Miriam","family":"Zacchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000348"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124534"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.08.012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/317542a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nature02030"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593841"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.60"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.5009"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-021-00613-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019030298"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.03.013"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.11.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.07.021"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5266.1339"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97046-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3871"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00167.2018"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.58"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1086\/423903"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101785"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/ng935"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ng1771"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1086\/510256"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.8.865"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1086\/341031"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00450-7"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1086\/368204"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1086\/498323"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2015.1066830"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nature04370"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1086\/519494"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu441"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu044"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.023"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddad112"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/ng.826"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-100737"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/79116"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/ng.97"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-020-00472-y"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2012.689411"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600158103"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191184"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2681"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.028"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.05.002"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.002"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/ng2072"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/ng1217"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.12.011"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040490"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-149"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1038\/ng1216"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1086\/340317"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1038\/ng.756"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.10.001"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40076"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.11.003"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2021.10.004"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-2054-y"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.06.023"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.08.015"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.05.010"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.019"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-72"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103087"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24127"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060945"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.09.009"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-103832"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1078"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.02.011"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.11.019"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003544"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.02.018"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12752"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22470"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0858-z"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22821"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15442-1"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14980"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1086\/421846"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.002"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3201"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1038\/ng2039"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.08.017"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.06.017"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3273"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213506"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1038\/ng.594"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2020.100016"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101132"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.005"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131656"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr151"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.06.003"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.05.004"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13012"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.254"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12301"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.02.017"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21507"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv242"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101431"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1099-5"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1038\/73508"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1086\/368063"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv152"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1038\/ng867"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1038\/ng1520"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70083-6"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1681\/asn.v13175"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1086\/344395"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9666"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12196"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38215"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.04.016"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201911739"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.09.012"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.10.003"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.022"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.59"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/461524"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab218"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-016-0084-3"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.289"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910672106"},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-947-5_8"},{"key":"ref130","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002732022"},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9978571"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310459"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.02.347"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-00724-z"},{"key":"ref135","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-974-1_12"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048546"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1038\/ni0707-665"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.05.002"},{"key":"ref139","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.012"},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.009"},{"key":"ref141","doi-asserted-by":"publisher","DOI":"10.1002\/cpmo.22"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00717-z"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13398-6"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95986-5"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020030378"},{"key":"ref146","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01202-z"},{"key":"ref147","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101667"},{"key":"ref148","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.101881"},{"key":"ref149","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000029587.47950.25"},{"key":"ref150","doi-asserted-by":"publisher","DOI":"10.1038\/ng1076"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005080830"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030234"},{"key":"ref153","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V124834"},{"key":"ref154","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005050534"},{"key":"ref155","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030295"},{"key":"ref156","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007070828"},{"key":"ref157","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6397"},{"key":"ref158","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2008.07.021"},{"key":"ref159","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn180"},{"key":"ref160","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.21.303"},{"key":"ref161","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32543-2"},{"key":"ref162","doi-asserted-by":"publisher","DOI":"10.1161\/circ.146.suppl_1.15380"},{"key":"ref163","doi-asserted-by":"publisher","DOI":"10.1113\/JP283895"},{"key":"ref164","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214053"},{"key":"ref165","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.001723"},{"key":"ref166","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211670"},{"key":"ref167","doi-asserted-by":"publisher","DOI":"10.3906\/biy-1805-25"},{"key":"ref168","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169420"},{"key":"ref169","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101654"},{"key":"ref170","doi-asserted-by":"publisher","DOI":"10.1007\/s10404-023-02629-4"},{"key":"ref171","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247125"},{"key":"ref172","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0595"},{"key":"ref173","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9715"},{"key":"ref174","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.047"},{"key":"ref175","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12651"},{"key":"ref176","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061326"},{"key":"ref177","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.06.141"},{"key":"ref178","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252156"},{"key":"ref179","doi-asserted-by":"publisher","DOI":"10.1038\/NMAT4994"},{"key":"ref180","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107841"},{"key":"ref181","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145140"},{"key":"ref182","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113431"},{"key":"ref183","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.03.005"},{"key":"ref184","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.06.005"},{"key":"ref185","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz232"},{"key":"ref186","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021040460"},{"key":"ref187","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.06.057"},{"key":"ref188","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00135.2012"},{"key":"ref189","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322373111"},{"key":"ref190","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80657"},{"key":"ref191","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.06.009"},{"key":"ref192","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.12.001"},{"key":"ref193","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2017.11.003"},{"key":"ref194","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050113"},{"key":"ref195","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2023.2218616"},{"key":"ref196","doi-asserted-by":"publisher","DOI":"10.1039\/c7lc00134g"},{"key":"ref197","doi-asserted-by":"publisher","DOI":"10.1039\/c3ib40049b"},{"key":"ref198","doi-asserted-by":"publisher","DOI":"10.1039\/c6tx00417b"},{"key":"ref199","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95978"},{"key":"ref200","doi-asserted-by":"publisher","DOI":"10.1038\/srep31771"},{"key":"ref201","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119367"},{"key":"ref202","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00466-9"},{"key":"ref203","doi-asserted-by":"publisher","DOI":"10.1063\/1.5081756"},{"key":"ref204","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.624553"},{"key":"ref205","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35537-2"},{"key":"ref206","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq0866"},{"key":"ref207","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2016-0085"},{"key":"ref208","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.06.034"},{"key":"ref209","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124537"},{"key":"ref210","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00127"},{"key":"ref211","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15511.2"},{"key":"ref212","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.653138"},{"key":"ref213","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020668"},{"key":"ref214","doi-asserted-by":"publisher","DOI":"10.1042\/BST20200757"},{"key":"ref215","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.61.477"},{"key":"ref216","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0490-0"},{"key":"ref217","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.137"},{"key":"ref218","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121090"},{"key":"ref219","doi-asserted-by":"publisher","DOI":"10.1038\/nm1004"},{"key":"ref220","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3565(24)37873-5"},{"key":"ref221","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011498108"},{"key":"ref222","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.06.026"},{"key":"ref223","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04248-9"},{"key":"ref224","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00095.2022"},{"key":"ref225","doi-asserted-by":"publisher","DOI":"10.33594\/000000072"},{"key":"ref226","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19057"},{"key":"ref227","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2023.10.005"},{"key":"ref228","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15652"},{"key":"ref229","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0216220"},{"key":"ref230","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104751"},{"key":"ref231","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002490R"},{"key":"ref232","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158499"},{"key":"ref233","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.971219"},{"key":"ref234","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.08.036"},{"key":"ref235","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41106-3"},{"key":"ref236","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00937-z"},{"key":"ref237","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95874"},{"key":"ref238","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx349"},{"key":"ref239","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11918-y"},{"key":"ref240","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.01.026"},{"key":"ref241","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15058"},{"key":"ref242","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020111560"},{"key":"ref243","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.02.008"},{"key":"ref244","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37449-1"},{"key":"ref245","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22169013"},{"key":"ref246","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07300-x"},{"key":"ref247","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw3593"},{"key":"ref248","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16903"},{"key":"ref249","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911987106"},{"key":"ref250","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000209"},{"key":"ref251","doi-asserted-by":"publisher","DOI":"10.1007\/BF00853593"},{"key":"ref252","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08284-4"},{"key":"ref253","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21132-3"},{"key":"ref254","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v6.i4.188"},{"key":"ref255","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.0610s1125.x"},{"key":"ref256","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1164"},{"key":"ref257","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00625.x"},{"key":"ref258","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa138"},{"key":"ref259","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.139"},{"key":"ref260","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.147"},{"key":"ref261","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr550"},{"key":"ref262","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.04.014"},{"key":"ref263","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2115960119"},{"key":"ref264","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1976-2"},{"key":"ref265","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0907419"},{"key":"ref266","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1003491"},{"key":"ref267","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00242.2018"},{"key":"ref268","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2011.620055"},{"key":"ref269","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-020-00294-9"},{"key":"ref270","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2015010016"},{"key":"ref271","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23862"},{"key":"ref272","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2023.100668"},{"key":"ref273","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-00963-4"},{"key":"ref274","doi-asserted-by":"publisher","DOI":"10.3390\/genes14030764"},{"key":"ref275","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-020-00475-6"},{"key":"ref276","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019222108"},{"key":"ref277","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.12.007"},{"key":"ref278","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.03.005"},{"key":"ref279","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S338653"},{"key":"ref280","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.04.027"},{"key":"ref281","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000768"},{"key":"ref282","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809432115"},{"key":"ref283","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180508095654"},{"key":"ref284","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12703"},{"key":"ref285","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S338653"},{"key":"ref286","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-020-01110-1"},{"key":"ref287","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(98)03495-3"},{"key":"ref288","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-017-1477-7"},{"key":"ref289","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009020162"},{"key":"ref290","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000013300.11876.37"},{"key":"ref291","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.101707.125712"},{"key":"ref292","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv456"},{"key":"ref293","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.02.008"},{"key":"ref294","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.01.040"},{"key":"ref295","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17249417"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:58:12Z","timestamp":1755496692000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":295,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547131","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}