{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:32Z","timestamp":1787017952134,"version":"build-2736575974"},"reference-count":68,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"abstract":"<jats:p>Introduction: The aim of the study was to compare obstetrical, survival, and nephro-urological outcomes of fetuses diagnosed with lower urinary tract obstruction (LUTO) undergoing antenatal procedures by vesicoamniotic shunting (VAS) or fetal cystoscopy (FC). Methods: This study was a literature search using MEDLINE, Scopus, Embase, and Cochrane reference lists. All studies reporting VAS and FC\u2019s effectiveness, complications, and technical issues in the prenatal treatment of LUTO were selected for a single-proportion meta-analysis. Two reviewers independently selected studies, extracted data, and assessed quality. We computed and declared effect sizes for estimating a single proportion using the Freeman-Turkey transformed proportion. Results: Out of a total of 467 citations identified, 49 studies were included for a detailed evaluation of VAS and FC perinatal outcomes. Overall, VAS and FC were burdened by a similar incidence of intrauterine fetal demise (VAS: 0.51 [0.42\u20130.61] vs. FC: 0.47 [0.28\u20130.67]; p = 0.73), postnatal death (VAS: 0.87 [0.75\u20130.99] vs. FC: 0.86 [0.62\u20131.09]; p value: 0.87), and postnatal renal impairment (VAS: 1.22 [1.06\u20131.39] vs. FC: 0.96 [0.67\u20131.25]; p value: 0.12). Likewise, the two procedures were complicated by a similar rate of chorioamnionitis (VAS: 0.38 [0.28\u20130.47] vs. FC: 0.39 [0.12\u20130.66]; p value: 0.92), premature rupture of membranes\/preterm premature rupture of membranes (VAS: 0.77 [0.60\u20130.94] vs. FC: 0.84 [0.60\u20131.07]; p value: 0.65), premature birth (VAS: 1.83 [1.55\u20132.10] vs. FC: 1.56 [0.92\u20132.21]: p value: 0.46), and fetal abdominal wall\/intestinal problems (VAS: 0.43 [0.29\u20130.57] vs. FC: 0.50 [0.19\u20130.81]; p value: 0.69). Termination of pregnancy (TOP) was chosen significantly more often after FC than VAS (VAS: 0.65 [0.53\u20130.77] vs. FC: 1.18 [1.03\u20131.33]; p value: &lt;0.001). Conclusion: Our meta-analysis yields similar results in terms of obstetric, survival, and nephro-urological outcomes between VAS and FC. The higher incidence of TOP in FC over the VAS group may be associated with the fact that FC is also considered a diagnostic tool and can guide for TOP for those with more complex diseases.<\/jats:p>","DOI":"10.1159\/000547182","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:00:50Z","timestamp":1756828850000},"page":"279-302","source":"Crossref","is-referenced-by-count":3,"title":["Fetal Cystoscopy and Vesicoamniotic Shunting in Lower Urinary Tract Obstruction: A Meta-Analysis of Long-Term Outcome and Current Technical Limitations"],"prefix":"10.1159","volume":"53","author":[{"given":"Irene","family":"Paraboschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-5122","authenticated-orcid":false,"given":"Ugo 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