{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:16:39Z","timestamp":1780316199592,"version":"3.54.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"abstract":"<jats:p>&lt;p&gt;Introduction: Postoperative radiation therapy (RT) is recommended for completely resected T1-2 salivary gland cancer (SGC), if the tumor pathology is adenoid cystic carcinoma, intermediate, or high-grade tumors. In this case series, we reviewed cases of intermediate- or high-grade SGC, managed with curative surgery alone without adjuvant RT, and compared those outcomes with pathology- and tumor stage-matched SGC, treated with surgery and postoperative RT. Methods: We retrieved cases of intermediate- or high-grade tumors arising from the major salivary glands treated with surgery alone without adjuvant RT (N = 29) from the institutional SGC database. The main reasons for no adjuvant RT and treatment outcomes were reviewed in detail. In addition, we established the tumor pathology (grade)- and tumor stage (T1-2N0M0)-matched cases treated with surgery and postoperative RT as comparison groups (N = 59), to investigate relative treatment outcomes. Results: The overall treatment outcome was 82.7% disease-specific survival (DSS) at a median follow-up of 41 months, with a 10.3% incidence of systemic metastasis in intermediate- or high-grade SGCs treated with surgery alone. The primary reasons for not receiving adjuvant RT were no recommendation by the surgeon (37.9%) and patient refusal of RT (27.6%). Comparisons of the surgery alone and surgery with postoperative RT in tumor pathology (grade)- and tumor stage-matched groups revealed similar treatment outcomes; 100% DSS at 35\u201350 months in the surgery alone group and 90\u2013100% DSS at 37\u201360 months in the surgery and postoperative RT group. Meanwhile, patients with advanced SGCs (T3-4 or N+) treated with surgery alone had a DSS of 50.0% at a median follow-up of 63 months, and systemic metastasis was the main cause of treatment failure (37.5%). Conclusion: Our findings suggest that surgery alone may yield favorable outcomes for a specific subset of early-stage, intermediate- to high-grade SGCs without any adverse pathological features. Further studies are warranted to validate this approach. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000547198","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T12:02:14Z","timestamp":1751198534000},"page":"116-125","source":"Crossref","is-referenced-by-count":1,"title":["Surgery Alone without Adjuvant Radiation Therapy for High- or Intermediate-Grade Salivary Gland Cancer"],"prefix":"10.1159","volume":"87","author":[{"given":"Younghac","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-0573","authenticated-orcid":false,"given":"Han-Sin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00449"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100602"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4578-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24375"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.08.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06205-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.2.96"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.08.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0347(199703)19:23.0.co;2-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0003489417702655"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.158"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/0194599817717661"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2023.11.006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.03.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815601659"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31535"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s41199-018-0032-x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25603"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26135"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1229493"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01420-1"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-009-0102-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0795-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.715"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000497438"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.11.045"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27203"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:01:42Z","timestamp":1761321702000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":29,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2025,10,24]]},"published-print":{"date-parts":[[2025,10,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000547198","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29430485","asserted-by":"subject"}]},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]}}}