{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:02:19Z","timestamp":1775570539492,"version":"3.50.1"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Introduction: In immunocompromised individuals, particularly organ transplant recipients, the risk of developing Kaposi sarcoma (KS) increases significantly due to prolonged immunosuppressive therapy. The onset of post-transplant KS is highly variable, though most cases occur within the first 2 years following transplantation. The effectiveness and safety of systemic therapies, in the management of post-transplant KS are not well established. In this report, we describe a rare case of early-onset KS in a Tunisian kidney transplant recipient, revealed by deep vein thrombosis just 6 months after transplantation and successfully managed with paclitaxel as first-line therapy. Case Presentation: We present the case of a 52-year-old Tunisian male who underwent a living-donor kidney transplant in June 2022. Six months after transplantation, the patient presented with deep vein thrombosis and large purplish plaques were observed on the anterior left thigh. A skin biopsy confirmed the diagnosis of KS. Further Investigations revealed systemic involvement. The patient was treated with paclitaxel-based chemotherapy in combination with sirolimus and a reduction in immunosuppressive therapy. As of November 2024, the patient had demonstrated marked clinical improvement, with resolution of KS lesions and stable renal function. Conclusion: This case of early-onset KS highlights the potential effectiveness of paclitaxel-based chemotherapy combined with sirolimus and a carefully adjusted reduction in immunosuppressive therapy as a promising first-line treatment option.<\/jats:p>","DOI":"10.1159\/000547250","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:51:35Z","timestamp":1770648695000},"page":"334-341","source":"Crossref","is-referenced-by-count":1,"title":["Kaposi\u2019s Sarcoma in a Kidney Transplant Recipient: A Case Report on Paclitaxel Response"],"prefix":"10.1159","volume":"19","author":[{"given":"Hiba","family":"Ghabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Trabelsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alia","family":"Zheni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syrine","family":"Tlili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamia","family":"Rais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fethi","family":"Ben Hmida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikram","family":"Mami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouhamed Karim","family":"Zouaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01830024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000601"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy262"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12694"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.12.036"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm089"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-229681"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318205b3e5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.03.028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042831"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032866"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20911.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-021-00855-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.4236\/ojneph.2024.141012"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:00:55Z","timestamp":1772816455000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547250","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.31281727","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]}}}