{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:14:59Z","timestamp":1764609299481,"version":"3.46.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Gas exchange and perfusion are impaired during neonatal cardiopulmonary resuscitation. Continuous chest compressions with asynchronous ventilation (CCCaV) improve oxygenation and hemodynamics in term animal models compared to synchronized 3:1 compressions-to-ventilation (C:V). We hypothesized that CCCaV improves gas exchange and hemodynamics in preterm lambs. Methods: Sixteen extremely preterm (124\u2013126 days gestation) lambs were asphyxiated to cardiac arrest by umbilical cord occlusion. Lambs were randomized to 3:1 C:V following the International Liaison Committee on Resuscitation algorithm or CCCaV (120 compressions and 40 asynchronized ventilations per minute). Epinephrine was given 3 min into resuscitation and repeated every 3 min until return of spontaneous circulation (ROSC). Results: All lambs achieved ROSC with no difference in time to ROSC. There was no difference in cerebral oxygen delivery (C-DO&lt;sub&gt;2&lt;\/sub&gt;) in lambs resuscitated with CCCaV versus 3:1 C:V (0.05 [0.041] vs. 0.03 [0.031] mL O&lt;sub&gt;2&lt;\/sub&gt;\/kg\/min, respectively) during chest compressions. CCCaV yielded higher arterial oxygen content (CaO&lt;sub&gt;2&lt;\/sub&gt; 2.07 [1.00] vs. 1.07 [0.69] mL O&lt;sub&gt;2&lt;\/sub&gt;\/dL), mean arterial pressure (14.2 [2.6] vs. 13.2 [2.3] mm Hg), and diastolic pressure (8.1 [1.8] vs. 7.1 [1.4] mm Hg) during chest compressions compared to 3:1 C:V. There was no difference in plasma reduced to oxidized glutathione [GSH\/GSSG ratio] between groups at 10 min post-ROSC. Discussion: CCCaV in asystolic preterm lambs did not alter C-DO&lt;sub&gt;2&lt;\/sub&gt;, frequency, or time to ROSC compared to standard 3:1 C:V resuscitation but increased CaO&lt;sub&gt;2&lt;\/sub&gt;, mean, and diastolic arterial pressure compared to 3:1 C:V without increasing plasma oxidative stress markers.<\/jats:p>","DOI":"10.1159\/000547332","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T16:02:42Z","timestamp":1754064162000},"page":"704-713","source":"Crossref","is-referenced-by-count":0,"title":["Continuous Chest Compressions with Asynchronous Ventilation in Asphyxiated Preterm Lambs with Asystole"],"prefix":"10.1159","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-0057","authenticated-orcid":false,"given":"Evan","family":"Giusto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Lesneski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Persiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Valdez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Hammitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2155","authenticated-orcid":false,"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payam","family":"Vali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202007-2997OC"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0095-5108(18)30039-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.03.009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2024.114058"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.06.007"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2022-324529"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000895"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176478"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-01306-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-023-02820-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316610"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092010410"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.095"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.70"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2019.01.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.11.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.07.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.06.056"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2006.06.008"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440080084029"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032270"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003898"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.03.228"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308363"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.1660"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:12:30Z","timestamp":1764609150000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12,1]]},"published-print":{"date-parts":[[2025,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000547332","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29757005","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}