{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:58:32Z","timestamp":1780937912835,"version":"3.54.1"},"reference-count":39,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"abstract":"<jats:p>Introduction: Obesity is associated with chronic kidney disease (CKD) incidence and progression. We examined whether bariatric surgery is associated with change in eGFR trajectory among patients with and without CKD. Methods: Patients who underwent bariatric surgery at two health systems were identified using ICD-9\/ICD-10 and CPT codes. Linear mixed models were fit on estimated glomerular filtration rate (eGFR) trajectory pre- and post-surgery among patients with or without CKD. Models were adjusted for age, sex, race, ethnicity, body mass index, hypertension, diabetes, follow-up duration, and type of bariatric surgery. Post-surgery, eGFR trajectory among patients with CKD was also compared following 1:2 propensity score matching to (1) patients without CKD who underwent surgery and (2) patients with CKD who did not undergo surgery. Results: Patients with CKD (n = 139) at Michigan Medicine had a slower annual rate of eGFR decline post-surgery compared to patients without CKD (n = 278) (1.54 [\u22122.26, \u22120.81] vs. 3.15 [\u22123.41, \u22122.87] mL\/min\/1.73 m2; p &lt; 0.001), despite adjusting for degree of weight loss. Among patients with CKD, surgery was associated with a slower annual rate of eGFR decline (\u22120.20 [\u22120.83, 0.43] post-surgery vs. \u22121.11 [\u22121.37, \u22120.85] mL\/min\/1.73 m2 for non-surgery patients; p &lt; 0.001). In an external validation study of patients with CKD in the Providence health system, bariatric surgery predicted an average increase in annualized eGFR slope by 1.19 [0.12, 2.25] mL\/min\/1.73 m2 (p = 0.03). Conclusion: Bariatric surgery is associated with less eGFR decline and may have weight-independent effects on preserving kidney function among persons living with obesity and CKD.<\/jats:p>","DOI":"10.1159\/000547339","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T16:02:33Z","timestamp":1753372953000},"page":"305-315","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Impacts of Bariatric Surgery on eGFR in CKD Patients"],"prefix":"10.1159","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-0449","authenticated-orcid":false,"given":"Siddharth S.","family":"Madapoosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5852-1209","authenticated-orcid":false,"given":"Lindsey M.","family":"Kornowske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn B.","family":"Daratha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cami R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-0103","authenticated-orcid":false,"given":"Katherine R.","family":"Tuttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura H.","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2009.01.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-011-0356-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041498.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2317"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-011-0472-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.09.020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft262"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307591"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2018.10.04"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-04909-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.18169"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.34067\/kid.0004982020"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2012.12.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600869"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0862-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v042.i08"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-025-07669-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.2229"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.06.024"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-023-00500-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46197"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.06.007"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2722-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v111.i09"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.01.010"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6458-8"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-04812-w"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0005312021"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.72"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft302"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011050476"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.02.039"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-022-06329-w"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1134644"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12100967"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.21105\/joss.00772"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003627"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0323-4"}],"container-title":["American 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