{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:45:36Z","timestamp":1765370736072,"version":"3.46.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;p&gt;Background: HER2-positive breast cancer is generally correlated with poor prognosis, whereas it demonstrates a favorable response to HER2-targeted therapies. Typically, HER2-positive tumors present as solid masses, while cystic features are exceedingly rare. Case Presentation: We present a case of a 37-year-old female with imaging findings of a large cystic mass (9.9 \u00d7 1.8 cm) in the left breast. Pathological examination confirmed grade III invasive carcinoma of no special type with HER2 positivity and HR positivity, low tumor-infiltrating lymphocytes (TILs, 5%), and high PD-L1 expression (CPS = 25%). The patient underwent a modified radical mastectomy with axillary lymph node dissection, revealing metastasis in 7 of 15 lymph nodes and the presence of lymphovascular invasion. Adjuvant therapy with the TCbHP regimen (docetaxel, carboplatin, pertuzumab, and trastuzumab) was initiated, with a total of six cycles planned, followed by maintenance therapy with trastuzumab and pertuzumab (HP) for 1 year. To date, the patient has tolerated the treatment well without evidence of distant recurrence or metastasis. Conclusion: This case underscores the discordance between radiological and pathological findings in breast cancer, highlighting the clinical significance of low TILs and high PD-L1 expression in HER2-positive tumors, and emphasizes the importance of individualized surgical and adjuvant treatment strategies. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000547386","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T16:02:40Z","timestamp":1753113760000},"page":"1129-1135","source":"Crossref","is-referenced-by-count":0,"title":["Cystic-Like HER2-Positive Breast Cancer with Low Tumor-Infiltrating Lymphocytes and High Programmed Death-Ligand 1 Expression in a Young Woman: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Minjun","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1737-628X","authenticated-orcid":false,"given":"Zhijian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.3322\/caac.21834"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1186\/s12905-024-02924-4"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/S0140-6736(16)32417-5"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.4314\/ahs.v23i3.31"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1186\/s43055-023-01063-4"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1007\/s10549-021-06287-4"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.3390\/cancers15184479"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1158\/1055-9965.EPI-13-1170"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1002\/path.2763"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1038\/s41591-018-0014-x"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1038\/nrclinonc.2015.215"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1038\/s41698-021-00163-6"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1172\/JCI80011"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1186\/s13058-024-01932-4"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1186\/s13045-022-01292-6"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:12:42Z","timestamp":1765357962000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547386","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29559323","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,7,21]]}}}