{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:03:08Z","timestamp":1775149388885,"version":"3.50.1"},"reference-count":41,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"abstract":"<jats:p>Introduction: We aimed to report the prevalence of mild cognitive impairment (MCI) among healthcare-seeking Indian older adults and study the relationship between serum leptin and adiponectin with MCI. Methods: This cross-sectional study, conducted in a tertiary care center\u2019s Memory Clinic in India, utilized Clinical Dementia Rating (CDR) for patient categorization. Patients with a CDR of 0.5 were diagnosed with MCI, excluding those with a CDR &gt;1. Biochemical markers, including leptin and adiponectin, were measured using ELISA. Results: During the study period of 2 years, 163 patients were included. Among them, 84 (52%) had MCI, and 58 (69%) had amnestic MCI. Patients with MCI were older (69.4 vs. 67.4, p = 0.048) and more prevalent in males (29 [72.50%] vs. 11 [44.72%], p = 0.002). Poor education and lower socio-economic status were associated with MCI. Among comorbidities and geriatric syndromes, multi-morbidity (OR: 7.35; 95% CI: 3.44\u201315.69), diabetes (OR: 2.65; 95% CI: 1.25\u20135.63), cerebrovascular accident (OR: 27.68; 95% CI: 6.18\u2013124.06), chronic obstructive pulmonary disease (OR: 4.77; 95% CI: 2.11\u201310.76), coronary artery disease (OR: 6.64; 95% CI: 2.30\u201319.12), and urinary incontinence (OR: 5.63; 95% CI: 2.25\u201314.11) were associated with MCI. Adiponectin was significantly lower in patients with MCI (1.36 vs. 2.50, p = 0.003), whereas serum leptin was higher (2.56 vs. 2.46, p = 0.827) but not significant after adjusting for age, sex, diabetes, and coronary artery disease. Conclusion: In healthcare-seeking older patients MCI is prevalent and low serum adiponectin may serve as a valuable marker. Addressing multi-morbidity early at the primary care level could be a promising strategy for preventing dementia.<\/jats:p>","DOI":"10.1159\/000547481","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:37Z","timestamp":1753891237000},"page":"85-94","source":"Crossref","is-referenced-by-count":0,"title":["Study of Leptin and Adiponectin among Indian Older Adults with Mild Cognitive Impairment: Initial Experience of Memory Clinic from a Geriatric Tertiary Care Center in India"],"prefix":"10.1159","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-4372","authenticated-orcid":false,"given":"Abhijith 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