{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T16:40:21Z","timestamp":1756226421285,"version":"3.44.0"},"reference-count":12,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"abstract":"<jats:p>Introduction: Mast cell sarcoma (MCS) is a rare and aggressive neoplasm with limited cytologic description, particularly in effusion specimens. Case Presentation: A 55-year-old man presented with a small intestinal tumor and peritoneal dissemination. Ascitic fluid cytology revealed numerous large atypical cells with round to horseshoe-shaped nuclei and abundant cytoplasm containing metachromatic granules. Some cells displayed hand mirror-like morphology. Immunocytochemistry showed CD117 and tryptase positivity, and a KIT D816Y mutation was identified. The diagnosis of MCS was later confirmed by biopsy. Conclusion: This is the first reported case of MCS diagnosed by effusion cytology. Recognition of hand mirror-like morphology and metachromatic granules, combined with immunocytochemistry and molecular analysis, may support early diagnosis. <\/jats:p>","DOI":"10.1159\/000547483","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T16:02:51Z","timestamp":1752854571000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Mast Cell Sarcoma of the Small Intestine Diagnosed by Ascitic Fluid Cytology: A Case Report with Molecular and Immunophenotypic Correlation"],"prefix":"10.1159","author":[{"given":"Kai","family":"Mizoguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-0710","authenticated-orcid":false,"given":"Yuki","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Otsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seigi","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoshige","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Furuhata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01014-w"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11812"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1931-x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200154"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000528887"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/72.4.551"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb08170.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.06.030"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.04.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102487"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1964-1"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T16:00:41Z","timestamp":1756224041000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":12,"URL":"https:\/\/doi.org\/10.1159\/000547483","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29581283","asserted-by":"subject"}]},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2025,7,18]]}}}