{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:47:04Z","timestamp":1779400024040,"version":"3.53.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;p&gt;Introduction: BCR::ABL1+ fusion is associated with chronic myelogenous leukemia and precursor B acute lymphoblastic leukemia. Though rare, there has been continued reporting of acute myeloid leukemia (AML) with BCR::ABL1+ fusion. We report two such cases. Case Presentations: The first is a 38-year-old male, who has been human immunodeficiency virus positive since 2004, with leukocytosis and numerous circulating blasts that showed evidence of a BCR::ABL1+ fusion rearrangement in the 91% of the cells analyzed via fluorescence in situ hybridization. He responded well to tyrosine kinase inhibitor combined chemotherapy. He was free of disease at 2 years of treatment but showed minimal residual disease at the molecular level 6 years after initial presentation. The second is a 69-year-old female with anemia, thrombocytopenia, and 25% circulating blasts. Her flow cytometric analysis revealed a CD34+ and CD117+ immature myeloid blast population. Her initial cytogenetic analysis showed t(9;22) translocation with loss of chromosomes 12 and 17, derivative of chromosome 1, pericentric inv(17), and two small marker chromosomes. Reverse transcription polymerase chain reaction revealed p190 and p210 BCR::ABL1+ fusion transcripts. She received multiple combinations of chemotherapy, consisting of dasatinib, cytarabine, and idarubicin. The patient showed persistent disease at 18 months of therapy with detectable BCR::ABL1+ transcripts in peripheral blood. The complex genetic profile of her cancer is likely the reason for her poor response, compared to the first patient. She was lost to follow-up. Conclusion: With ever improving therapy available and few cases in the literature, correct and timely diagnosis with proper management of AML with BCR::ABL1+ is warranted. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000547487","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T16:01:06Z","timestamp":1753977666000},"page":"1198-1206","source":"Crossref","is-referenced-by-count":1,"title":["Acute Myeloid Leukemia with BCR::ABL1+ Fusion: A Report of Two Cases and Review of Literature"],"prefix":"10.1159","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-232X","authenticated-orcid":false,"given":"Dominik S.","family":"Dabrowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilasha","family":"Ghildyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusella","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-1112","authenticated-orcid":false,"given":"Rodney E.","family":"Shackelford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric X.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v128.22.4238.4238"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s44313-024-00016-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1309\/B4NVER1AJJ84CTUU"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2003.10.027"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401229"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23480"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-018-0147-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0371"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-91439-8_2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.096420"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/ijc.IJC_282_20"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2020.02.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01069-9"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:12:48Z","timestamp":1765357968000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547487","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29678204","asserted-by":"subject"}]},"ISSN":["1662-6575"],"issn-type":[{"value":"1662-6575","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]}}}