{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:19:57Z","timestamp":1783354797416,"version":"3.54.6"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Caries Res"],"abstract":"<jats:p>Introduction: Early childhood caries (ECC) is a significant public health issue, affecting nearly half of children worldwide. Severe ECC (S-ECC) is characterized by smooth-surface caries in children under 3 years old. Early dental eruption has been linked to a higher risk of ECC, as teeth are exposed to cariogenic environments longer. This study analyzes the association between the number of teeth at 12 and 24 months and the presence of S-ECC at 4 years of age. Methods: Data were obtained from the 2015 Pelotas Birth Cohort, which included all children born in Pelotas, Brazil, in 2015. The number of teeth at 12 and 24 months, reported by mothers, was the primary exposure, and S-ECC at 4 years was the outcome. Sugar consumption was analyzed as a potential mediator. Confounders included maternal education, family income, and child sex. Mediation analysis was conducted using PARAMED, and Poisson regression with robust variance estimated prevalence ratios, adjusting for confounders. A significance level of 0.05 was used. Results: The number of teeth at 12 and 24 months was positively associated with S-ECC at 4 years. However, the sugar consumption trajectory did not mediate these relationships. Conclusion: This study highlights a significant association between the number of teeth in early life and S-ECC development, independent of sugar consumption.<\/jats:p>","DOI":"10.1159\/000547511","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T16:03:09Z","timestamp":1752854589000},"page":"221-229","source":"Crossref","is-referenced-by-count":0,"title":["Is the Number of Teeth in Mouth an Indicator of Caries in Childhood? A Birth Cohort Study"],"prefix":"10.1159","volume":"60","author":[{"given":"J\u00falia Freire","family":"Danigno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina da Costa","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Cadermatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Freitas da Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-491X","authenticated-orcid":false,"given":"Fl\u00e1vio Fernando","family":"Demarco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12783"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-024-03635-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517750572"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-016-0234-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000529620"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-013-0035-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.156887"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04004-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2021.vol35.0059"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41411-y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211068743"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000529210"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx219"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12025"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.20396\/bjos.v21i00.8667095"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.121208.131413"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/ipd.12484"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02873-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2022.vol36.0092"}],"container-title":["Caries Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:02:26Z","timestamp":1783353746000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,6]]},"published-print":{"date-parts":[[2026,7,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000547511","archive":["Portico"],"relation":{},"ISSN":["0008-6568","1421-976X"],"issn-type":[{"value":"0008-6568","type":"print"},{"value":"1421-976X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]}}}