{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:48:32Z","timestamp":1759798112241,"version":"build-2065373602"},"reference-count":33,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"Introduction: This study aimed to evaluate the effect of cecal ligation and puncture (CLP)-induced sepsis on transcapillary PO<sub>2<\/sub> gradients (\u0394PO<sub>2<\/sub>) in contracting skeletal muscles. Methods: Male Wistar rats (n = 16, 10 weeks old) were randomly assigned to sham or CLP groups. Seven days after surgery, microvascular (PO<sub>2<\/sub>mv) and interstitial (PO<sub>2<\/sub>is) PO<sub>2<\/sub> levels in the tibialis anterior muscle were measured using the phosphorescence quenching method during the transition from rest to electrically induced muscle contractions. \u0394PO<sub>2<\/sub> was calculated as PO<sub>2<\/sub>mv minus PO<sub>2<\/sub>is. Results: At rest, there were no differences in PO<sub>2<\/sub>mv, PO<sub>2<\/sub>is, and \u0394PO<sub>2<\/sub> between the sham and CLP groups. The PO<sub>2<\/sub>mv and PO<sub>2<\/sub>is decreased during the transition from rest to contractions in both groups. During muscle contractions, the PO<sub>2<\/sub>mv and \u0394PO<sub>2<\/sub> were significantly lower in the CLP group than in the sham group (PO<sub>2<\/sub>mv, 7.79 \u00b1 5.03 vs. 4.43 \u00b1 2.23; \u0394PO<sub>2<\/sub>, 5.50 \u00b1 4.46 vs. 1.82 \u00b1 2.66 mm Hg; sham vs. CLP; p < 0.05). The \u0394PO<sub>2<\/sub> of the rats in the sham group remained unchanged; however, it markedly decreased during muscle contractions in the CLP group. Conclusion: Sepsis reduced \u0394PO<sub>2<\/sub> in contracting skeletal muscles. <\/jats:p>","DOI":"10.1159\/000547568","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T16:02:40Z","timestamp":1753372960000},"page":"266-273","source":"Crossref","is-referenced-by-count":0,"title":["Transcapillary PO2<\/sub> Gradients in Contracting Muscle of Rat Model of Sepsis"],"prefix":"10.1159","volume":"62","author":[{"given":"Narumi","family":"Fukuzaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8639-2521","authenticated-orcid":false,"given":"Kazuki","family":"Hotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Izawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hitosugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rin","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuri","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02950-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0995OC"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.214"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12867"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13072"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1102-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.1.40"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1113\/JP275170"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12833"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1113\/JP279608"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12870"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0034-5687(01)00195-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126\/science.241.4873.1649"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-016-0096-z"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00081.2005"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000918"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/cc9205"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(73)90064-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020964"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117562"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200004000-00012"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.157727"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00341.2012"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.017"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068924"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00073.2005"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00547.2005"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00889.2003"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00134.2022"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2024.00591"}],"container-title":["Journal 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