{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:45:24Z","timestamp":1765370724697,"version":"3.46.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers, with an increasing incidence worldwide. Chronic sun exposure is a major risk factor and lesions are usually observed on sun-exposed areas such as the face, neck, scalp, and hands. Imiquimod cream, an immune response modifier, has shown promising results in the management of selected cases of cSCC. Case Report: A 70-year-old, Filipino male presented with 3-year history of a slow growing erythematous plaque on the abdomen. Physical examination revealed a solitary, well-defined, erythematous plaque measuring 5 cm on the left lower quadrant of the abdomen. Histopathologic examination confirmed cSCC. The patient declined surgery and opted for topical treatment with imiquimod 5% cream, applied over 24 weeks for a total of 104 applications. Serial biopsies taken at multiple follow-up points and anatomic sites confirmed complete histologic clearance. Conclusion: This case highlights one of the few documented instances of histologic cure in a &gt;5 cm cSCC treated solely with imiquimod cream. It underscores the potential of imiquimod as a nonsurgical alternative and expands current treatment for patients who may not be suitable candidates for conventional surgical excision. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000547650","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:34Z","timestamp":1753891234000},"page":"382-390","source":"Crossref","is-referenced-by-count":0,"title":["Histologic Clearance of a Giant Cutaneous Squamous Cell Carcinoma with Imiquimod 5% Cream: A Case Report"],"prefix":"10.1159","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8194-7289","authenticated-orcid":false,"given":"Marie Everild Bernadine H.","family":"Nazal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zharlah","family":"Gulmatico-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara Melissa","family":"Torres-Culala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103293441306"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00516_1.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1003a66"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.11S2a167S"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.161249"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.01.055"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.291"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-00978-0"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:10:21Z","timestamp":1765357821000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547650","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29673629","asserted-by":"subject"}]},"ISSN":["1662-6567"],"issn-type":[{"type":"electronic","value":"1662-6567"}],"subject":[],"published":{"date-parts":[[2025,7,30]]}}}