{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:45:27Z","timestamp":1765370727013,"version":"3.46.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>&lt;p&gt;Introduction: We present the unique case of a pediatric patient who underwent intra-arterial melphalan chemotherapy and subsequently developed choroidal neovascularization. Case Presentation: A 6-year-old male with a history of nonhereditary unilateral group D retinoblastoma treated with intra-arterial melphalan, cryotherapy, and diode laser consolidative therapy presented to establish care. Initial evaluation revealed a regressed retinoblastoma lesion with chorioretinal scars and calcification scattered in the midperiphery. Notably, the macula was largely within normal limits without evidence of prior malignancy or scarring. However, 7 months after establishing care, imaging was significant for intraretinal fluid, subretinal fluid, and subfoveal fibrosis of the treated eye, suggestive of choroidal neovascularization. The patient was managed with anti-VEGF therapy with resolution of subretinal fluid and improved visual acuity. Conclusion: This case represents the first description and management of a patient developing choroidal neovascularization after receiving intra-arterial melphalan treatment for retinoblastoma. Careful monitoring of patients following intra-arterial melphalan chemotherapy treatment is critical due to the potential for vision loss, including choroidal neovascularization, which may be an under-reported complication. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000547747","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:11:10Z","timestamp":1765357870000},"page":"649-654","source":"Crossref","is-referenced-by-count":0,"title":["Choroidal Neovascularization following Intra-Arterial Melphalan Chemotherapy for Retinoblastoma"],"prefix":"10.1159","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6463-1976","authenticated-orcid":false,"given":"Noorhan","family":"Amani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Goldbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan L.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_866_19"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000091"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.822330"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3202-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12295"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-004-0392-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.026"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4406-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.0244"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25346"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.08.045"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.03.013"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.09.040"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315209"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303694"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.06.002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.04.056"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:11:11Z","timestamp":1765357871000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000547747","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29924009","asserted-by":"subject"}]},"ISSN":["1663-2699"],"issn-type":[{"value":"1663-2699","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]}}}