{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:00:34Z","timestamp":1778774434673,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Henoch-Sch\u00f6nlein purpura (HSP) is a systemic vessel vasculitis characterized by IgA- and complement-mediated vascular injuries. However, the precise mechanisms underlying disease progression and severity remain unclear. This study aimed to identify inflammation-related proteins and pathways associated with HSP and disease severity. Methods: Plasma samples from 10 patients with HSP and 10 healthy controls (HC) were analyzed using the Olink inflammation panel. Patients were categorized into simple purpura (HSP_S) and complex purpura (HSP_C) groups based on clinical manifestations. Clinical and laboratory characteristics were also collected for analysis. Results: Patients in HSP_C group showed significant higher level of 24-h urine protein quantification (p = 0.038). Among the 92 inflammation-related proteins analyzed, 13 were differentially expressed between patients with HSP and HC. Notably, Oncostatin M (OSM), interleukin-6 (IL-6), and transforming growth factor-\u03b1 (TGF-\u03b1) were significantly elevated in HSP patients. Compared with the HSP_S group, HSP_C group exhibited increased levels of fibroblast growth factors (FGF19), glial cell line-derived neurotrophic factor, HGF, and OSM. Pathway enrichment revealed upregulation of the JAK-STAT and PI3K-Akt signaling pathways in HSP_C group, suggesting their involvement in disease severity. Protein-protein interaction analysis identified OSM, IL-6, TGF-\u03b1, and IL-18 as key inflammatory hubs, with OSM showing the strongest correlation with systemic injury. Conclusions: This study provides novel insights into the inflammatory proteomic landscape of HSP patients, highlighting OSM as a potential biomarker of disease severity and systemic injury. The JAK-STAT and PI3K-Akt pathways may play central roles in HSP pathogenesis and represent potential therapeutic targets.<\/jats:p>","DOI":"10.1159\/000547772","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:01:28Z","timestamp":1756396888000},"page":"535-546","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Proteomic Profiling of Inflammatory Mediators in Henoch-Sch\u00f6nlein Purpura: Oncostatin M as a Key Cytokine Associated with Disease Severity"],"prefix":"10.1159","volume":"187","author":[{"given":"Jiajia","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faxing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8156-4580","authenticated-orcid":false,"given":"Jun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.031"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167346"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.18502\/ijaai.v22i3.13060"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01809-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.943912"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.02.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-014-0534-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202100170"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00657"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0066-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188718"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109818"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1239732"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.11.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.04.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-020-01968-8"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2020.1780918"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040865"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2024.148763"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13216621"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11068.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:01:40Z","timestamp":1777910500000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,4]]},"published-print":{"date-parts":[[2026,5,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000547772","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}