{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:38:34Z","timestamp":1789609114560,"version":"build-2803163510"},"reference-count":18,"publisher":"S. Karger AG","issue":"12","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"abstract":"<jats:p>Introduction: Dialysis-related amyloidosis (DRA) is a refractory complication of long-term dialysis caused by \u03b22-microglobulin (\u03b22MG) deposition. While \u03b22MG adsorption columns remove \u03b22MG, their impact on preventing re-surgery remains unclear. Methods: This a noninterventional, population-based cohort study used a large-scale medical claims database. This study included patients with chronic kidney disease undergoing maintenance hemodialysis (HD) and diagnosed with DRA. The exposure group received \u03b22MG adsorption column therapy, while the control group was divided into online hemodiafiltration (OHDF) and HD subgroups. The primary endpoint was carpal tunnel or trigger finger release. Results: Among 3,946 eligible patients, 212 patients in the \u03b22MG adsorption column group, 139 in the OHDF group, and 237 in the HD group were included; the primary endpoint occurred in 28 (13.2%), 21 (15.1%), and 37 (15.6%) patients, respectively. Although there was a trend toward a lower incidence in the \u03b22MG adsorption column group, no significant difference was observed (p = 0.43). The adjusted hazard ratio for the \u03b22MG adsorption column group (HD group as reference) tended to be low (0.68, 95% CI: 0.41\u20131.13), but this difference was not significant. Conclusions: Although there was no statistically significant difference, the findings suggest that the \u03b22MG adsorption column may help slow DRA progression.<\/jats:p>","DOI":"10.1159\/000547964","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:01:03Z","timestamp":1756396863000},"page":"764-771","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Therapeutic Effects of Beta2-Microglobulin Adsorption on Dialysis-Related Amyloidosis Using a Clinical Claims Database"],"prefix":"10.1159","volume":"54","author":[{"given":"Chikao","family":"Onogi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8866-5901","authenticated-orcid":false,"given":"Akihito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Furuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-024-00585-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.639799"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S84784"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00432-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytad239"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00235.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000330332"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.00937.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2004.47260.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-012-0024-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000346221"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33247-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2024.2315148"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000496631"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000001466"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66076"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0948-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100331"}],"container-title":["Blood Purification"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T17:00:58Z","timestamp":1765990858000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,16]]},"published-print":{"date-parts":[[2025,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000547964","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29938550","asserted-by":"subject"}]},"ISSN":["0253-5068","1421-9735"],"issn-type":[{"value":"0253-5068","type":"print"},{"value":"1421-9735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}