{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:06:20Z","timestamp":1758647180965,"version":"3.44.0"},"reference-count":14,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"abstract":"<jats:p>Introduction: The incidence of adhesive small bowel obstruction (ASBO) after abdominal surgery is 2.4%. Delay in surgery increases morbidity and mortality. Plasma intestinal fatty acid binding protein (I-FABP) levels indicate intestinal damage and may guide treatment. The aim of this study was to investigate whether plasma I-FABP levels may optimize selection of patients requiring surgery presenting with ASBO. Methods: Patients with suspected ASBO underwent a contrast swallow. If bowel transit was absent after 8 h, surgery was performed. I-FABP levels were assessed at several moments. Data were analyzed by comparing groups based on bowel transit, ischemia, and positive or negative laparotomies. Furthermore, a true operative group (patients with mechanical obstruction during surgery and patients needing operative treatment who deceased due to non-operative treatment) was compared to a true non-operative group (patients with negative laparotomies and patients successfully treated with non-operative treatment). Results: Median I-FABP levels were higher in patients without bowel transit (1,207 pg\/mL) than in patients with bowel transit (589 pg\/mL, p = 0.01). Median I-FABP levels in the negative laparotomy group (301 pg\/mL) showed a trend to significance compared to the positive laparotomy group (1,177 pg\/mL, p = 0.05). There was no significant difference between the true operative group (1,150 pg\/mL) and the true non-operative group (664 pg\/mL) or between proven ischemia (975 pg\/mL) and no ischemia (921 pg\/mL). Conclusion: I-FABP might help identify ASBO patients in whom surgery can be postponed. <\/jats:p>","DOI":"10.1159\/000547989","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T11:40:37Z","timestamp":1755171637000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Role of Intestinal Fatty Acid Binding Protein in Diagnosing Adhesive Small Bowel Obstruction: A Pilot Study"],"prefix":"10.1159","author":[{"given":"Juliette S.","family":"van Dam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire A.J.I.","family":"Leenarts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thijs R.","family":"van Oudheusden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joep P.M.","family":"Derikx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misha","family":"Luyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5588"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-6-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7489"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.587"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318207a767"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182a87e3e"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.05.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12194"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099915"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cursur.2006.05.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2015.06.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2014.073"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9182-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296004"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000547989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:00:54Z","timestamp":1758643254000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000547989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1159\/000547989","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]}}}