{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:04:53Z","timestamp":1765213493404,"version":"3.46.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"abstract":"<jats:p>Introduction: Interindividual variations in antidepressant dosages required to achieve and maintain a therapeutic response are common. To mitigate the risk of recurrence, it is recommended that patients maintain treatment at a dose that effectively alleviates their acute depressive symptoms for at least 6 months. This study investigated the relationship between the antidepressant doses used for maintenance therapy and genetic polymorphisms that affect serotonin transporter activity. Methods: Eighty-four Japanese patients with depression were enrolled in the study. For each patient, the doses of antidepressant and anxiolytic\/hypnotic medications were quantified as equivalents of imipramine and diazepam, respectively, based on the most recent prescription. Patients were divided into high- and low-dose antidepressant treatment groups, using the median dose as the between-group cutoff. We examined the influence of genetic polymorphisms on inclusion in the high- and low-dose groups. Results: Multivariate logistic regression analysis revealed that the presence of the G allele in the SLC22A3 rs2292334 polymorphism was associated with an increased antidepressant maintenance dose. The odds ratio for an increased presence in the G allele of the SLC22A3 rs2292334 polymorphism was 8.867 (95% confidence interval, 1.869\u201342.069). Conclusion: These findings have potential use in informing future dosing strategies in depression therapy.<\/jats:p>","DOI":"10.1159\/000548094","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:01:24Z","timestamp":1756396884000},"page":"277-284","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Organic Cation Transporter 3 (SLC22A3) Genetic Polymorphisms on Antidepressant Maintenance Doses in Japanese Patients with Depression"],"prefix":"10.1159","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9115-1870","authenticated-orcid":false,"given":"Kazuyuki","family":"Inoue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakeru","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Hakamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/515180a"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290080031005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/s003329170300744x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.07.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712002395"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.041"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2021.102744"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2008.01920.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2008.10.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00298"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000117498"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770070041003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(99)01150-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02446.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.03.012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00288.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.alc.0000150008.68473.62"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000143"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.048"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10521"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800466105"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5687-11.2013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1021\/cn500331z"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23103"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2011.60"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12275"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30217-2"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2017-0019"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.01.008"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407913200"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108574"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.211334"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708008547"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1080\/0097840X.1981.9934538"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/da.22045"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPO-2020-0122"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/ph17030280"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:01:47Z","timestamp":1765213307000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":38,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2025,12,8]]},"published-print":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000548094","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.29979202","asserted-by":"subject"}]},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}