{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:27:49Z","timestamp":1788553669758,"version":"build-2803163510"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Investigation the association between cerebral oxygenation and short-term adverse outcome in asphyxiated infants with hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH). Methods: Near infrared spectroscopic-derived cerebral oxygen saturation (rScO&lt;sub&gt;2&lt;\/sub&gt;) pattern during first 4 days was compared to early brain MRI (4\u201310 days) using the Weeke score to define MRI-derived brain injury of infants with GA &gt;35 weeks treated with TH within 6 h between 2010 and 2023. Weeke scores of &gt;9 were considered adverse short-term outcome. Infants with congenital abnormalities, chromosomal disorders, or on ECMO were excluded. Results: 292 infants (mean \u00b1 1 SD: GA 39.4 \u00b1 1.9 weeks; BW 3,442 \u00b1 621 g; median [IQR] 5-min Apgar score 4 [3]) were eligible. According to the Sarnat staging, HIE was mild, moderate, or severe in 77, 148, and 67 infants. Adverse short-term outcome\/death occurred in 0, 39 (26.4%), and 67 (100%) infants in mild, moderate, and severe HIE groups. Severe HIE infants had higher rScO&lt;sub&gt;2&lt;\/sub&gt; values compared to moderate or mild HIE infants. Mixed model analysis showed an association between rScO&lt;sub&gt;2&lt;\/sub&gt; (dependent variable), time after birth, adverse short-term outcome, and inhaled nitric oxide. Logistic regression showed that adverse outcome had a positive association with rScO&lt;sub&gt;2&lt;\/sub&gt; and first lactate levels. Discussion: High cerebral oxygen saturation during TH is associated with adverse short-term outcome. This knowledge may contribute to early counseling and decision-making. Combination with early blood lactate levels strengthened this association. Simultaneous NO-ventilation may confound this association.<\/jats:p>","DOI":"10.1159\/000548127","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:00:52Z","timestamp":1756828852000},"page":"741-750","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral Oxygenation Pattern during Therapeutic Hypothermia after Perinatal Asphyxia: A Single Center Cohort Study"],"prefix":"10.1159","volume":"122","author":[{"given":"Thomas","family":"Alderliesten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-8265","authenticated-orcid":false,"given":"Corline E.J.","family":"Parmentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon 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