{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:40:26Z","timestamp":1791607226159,"version":"4.3.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>&lt;p&gt;Introduction: Aminoglycosides, valued for their lower antimicrobial resistance, are used for perioperative antibiotic prophylaxis (PAP) in urological procedures such as robot-assisted radical prostatectomy (RARP). However, data regarding the safety of gentamicin in robot-assisted surgery remain limited. This study assessed the incidence of acute kidney injury (AKI) associated with PAP with single-dose gentamicin during the transition from open prostatectomy to RARP. Methods: This single-center, retrospective, matched case-control study included 77 RARP patients receiving gentamicin and 72 matched controls receiving cefuroxime. AKI was assessed using the Kidney Disease: Improving Global Outcome (KDIGO) criteria, considering age, comorbidities, and prostate weight. Results: AKI occurred in 33.8% of the gentamicin group versus 9.7% of the cefuroxime group, resulting in an odd\u2019s ratio (OR) of 6.25. In the gentamicin group, grade 1 AKI was most frequent (19.5%), followed by grade 2 (7.8%) and grade 3 (6.5%). In the cefuroxime group, grades 1 (5.6%) and 2 (4.2%) were observed. Prostate volume and gentamicin use emerged as independent cofactors. Limitations include missing long-term data, variable gland measurements, and inclusion of patients with pre-existing kidney disease. Conclusion: The risk of AKI was significantly higher after PAP with gentamicin compared to PAP with cefuroxime (OR: 6.25, 95% CI: 2.095\u201318.664, p = 0.001), suggesting that PAP with gentamicin should be avoided in RARP. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000548188","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:01:37Z","timestamp":1756396897000},"page":"213-219","source":"Crossref","is-referenced-by-count":1,"title":["Perioperative Gentamicin Prophylaxis in Robot-Assisted Prostatectomy Increases Acute Kidney Injury Risk"],"prefix":"10.1159","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7620-186X","authenticated-orcid":false,"given":"Michael","family":"Glietsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Blaschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Lux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Geginat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-2096","authenticated-orcid":false,"given":"Martin","family":"Schostak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2020.2087"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2015.0094"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2021.12.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13439"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009625.pub2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22875"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.027"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.03.06"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.2117"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.08.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.ESP-0002-2018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.01.068"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120568"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14682"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000509"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002650"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:04:55Z","timestamp":1780329895000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,1]]},"published-print":{"date-parts":[[2026,6,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000548188","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}