{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T20:51:49Z","timestamp":1764363109453,"version":"3.46.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"abstract":"<jats:p>Introduction: Stereoelectroencephalography-guided radio-frequency thermocoagulation (SEEG-RFTC) is a minimally invasive technique whereby radio-frequency thermocoagulation is performed using SEEG electrodes, following recording and stimulation. It helps to disconnect\/disrupt or ablate the epileptogenic networks and provides both therapeutic and diagnostic abilities. Methods: This study is a retrospective study (2016\u20132024). All underwent comprehensive epilepsy surgery workup (video EEG, MRI, ictal-SPECT, PET, and magnetoencephalography). SEEG was placed using robotic guidance. Recording of habitual seizure following stimulation (to produce seizures) was performed followed by SEEG-RFTC in the seizure onset zone (SOZ) at the bedside; electrodes were then explanted. If seizures recurred or were not controlled, this was followed by surgery over SOZ as guided by SEEG stimulation-induced functional mapping of eloquent cortices. Results: Sixty-one patients underwent SEEG-RFTC, 41 males. Mean duration of seizures was as follows: 11 years; seizure frequency range 1\u2013100\/day. As per imaging, 5 had definite lesions, 12 dual substrates (either adjacent or distant), 5 doubtful lesions, 21 non-lesional on MRI, 9 localization on SPECT\/PET\/MEG but MRI doubtful, 4 eloquent cortex involvement, and 5 had bilateral substrates. SOZ was frontal in 18, temporal 35, insula 3, occipital 4, parietal 1. A total of 406 electrodes were implanted, a mean of 8.2 \u00b1 3.5\/patient. Mean follow-up was 42 \u00b1 17.4 months. About 72% (44\/61) responded transiently (mean transient seizure-free time 95 \u00b1 19 days). Of these, 29 underwent surgery; 48% had good outcomes (classes 1 and 2). Overall, 22% (14\/61) had good outcomes with SEEG-RFTC as stand-alone procedure (follow-up 28 + 6.2 months, range 6\u201332 months). The class 1 and 2 outcomes were 37% in MRI-negative and 53.8% in MRI-positive cases (p &lt; 0.01). The transient seizure-free time in our study did not correlate with good outcomes, but presence or absence of a substrate did. Temporal substrates had better outcomes than extra-temporal (57% vs. 47%, classes 1 and 2, p &lt; 0.01). Conclusion: SEEG-RFTC is a minimally invasive and effective adjuvant to SEEG recording and stimulation, may be done bedside under awake conditions, and helps to disrupt\/disconnect\/ablate the abnormal networks. It may be therapeutic or can strengthen the hypothesis for a later surgical resection.<\/jats:p>","DOI":"10.1159\/000548196","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T16:01:00Z","timestamp":1756742460000},"page":"312-325","source":"Crossref","is-referenced-by-count":1,"title":["SEEG-Guided Radio-Frequency Thermocoagulation of the Epileptogenic Networks: Its Utility for Both Treatment and Validation for Localizing Epileptogenic Networks"],"prefix":"10.1159","volume":"103","author":[{"given":"Poodipedi Sarat","family":"Chandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-0061","authenticated-orcid":false,"given":"Ramesh Sharanappa","family":"Doddamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghavendra","family":"Honna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiswarya","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhavi","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Parihar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108023450501"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615335"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1715424"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32835ee5b8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3171\/CASE23321"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.01.012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebr.2021.100471"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/epi.18005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.07.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.01.023"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17673"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3171\/CASE23611"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.08.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2025.01.012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1958.02340120050007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.17704.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460070011001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03110200097026"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401728"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opx291"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2022.10.003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.06.095"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-8444-8_37"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-8592-6_13"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8958-9"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:01:06Z","timestamp":1764349266000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11,28]]},"published-print":{"date-parts":[[2025,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000548196","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30009061","asserted-by":"subject"}]},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"type":"print","value":"1011-6125"},{"type":"electronic","value":"1423-0372"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}