{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:12:43Z","timestamp":1790820763125,"version":"4.1.0"},"reference-count":59,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: This meta-analysis evaluates efficacy and safety of anti-reflux mucosal interventions (ARMIs) for gastroesophageal reflux disease (GERD), and comparative effectiveness against traditional interventions. Methods: A systematic search identified 37 studies (11 comparative and 26 single-arm studies) evaluating ARMIs. Outcomes included GERD symptom scores (GERD-Q, GERD-HRQL), DeMeester score, acid exposure time (AET), complete cessation of proton-pump inhibitor (PPI) therapy, and adverse events (AEs). Random-effects models pooled standardized mean differences and risk ratios (RRs). Subgroup analyses compared techniques (endoscopic mucosal resection [EMR], endoscopic submucosal dissection [ESD], anti-reflux mucosal ablation [ARMA]). Results: Technical success was 100%, with a mean procedure time of 42.09 min. ARMIs significantly reduced the proportion of patients using PPI (RR = 2.22\u20133.06; &lt;3\u201324 months; p \u2264 0.001) and improved GERD-Q, GERD-HRQL, and DeMeester scores through 36 months (p &lt; 0.05). AET decreased at 3\u20136 months (p &lt; 0.001). Overall AEs occurred in 13% of cases (bleeding: 3%; stricture: 8%; dysphagia: 8%). Subgroup analyses demonstrated efficacy across EMR, ESD, and ARMA subtypes (p &lt; 0.05), though AE rates differed. Compared to laparoscopic Nissen fundoplication (LNF), ARMIs showed similar symptom relief (p &gt; 0.05), shorter procedures (p &lt; 0.001), and lower dysphagia (X% vs. Y%; p = 0.01). Versus Stretta, ARMIs had similar PPI discontinuation rates (p = 0.258) and GERD-Q improvement (p = 0.696). Conclusion: ARMIs offer durable symptom control with reduced PPI dependency. Preliminary comparative data suggest potential efficacy\/safety advantages over LNF\/Stretta, warranting randomized trials. Technique selection should balance efficacy and AE profiles.<\/jats:p>","DOI":"10.1159\/000548198","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T16:01:15Z","timestamp":1757001675000},"page":"601-618","source":"Crossref","is-referenced-by-count":5,"title":["Endoscopic Anti-Reflux Mucosal Interventions for Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Efficacy, Safety, and Comparative 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