{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:09:25Z","timestamp":1764608965982,"version":"3.46.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: Periampullary masses encompass both benign and malignant lesions that are clinically challenging to differentiate. This study aimed to investigate the diagnostic value of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) for periampullary masses and compare its performance with computed tomography (CT) and magnetic resonance imaging (MRI). Methods: We conducted a retrospective analysis of 54 patients with pathologically confirmed malignant periampullary masses or benign lesions validated by \u22651-year follow-up. Diagnostic efficacy of CH-EUS was evaluated against CT and MRI. Results: All malignant masses exhibited arterial-phase hypo-enhancement, while 78.94% of benign lesions showed iso-enhancement. Venous-phase hypo-enhancement was observed in 94.28% of malignancies, and 57.89% of benign cases demonstrated iso-enhancement. CH-EUS demonstrated superior diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value compared to CT (all p &lt; 0.05). Its accuracy and sensitivity also exceeded those of MRI (p &lt; 0.05). Conclusion: CH-EUS effectively differentiates benign and malignant periampullary masses, demonstrating high clinical utility.<\/jats:p>","DOI":"10.1159\/000548246","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:00:21Z","timestamp":1756569621000},"page":"697-705","source":"Crossref","is-referenced-by-count":0,"title":["The Value of Contrast-Enhanced Harmonic Endoscopic Ultrasound in the Diagnosis of Periampullary Mass"],"prefix":"10.1159","volume":"43","author":[{"given":"Shu-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25336"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3233\/CH-221390"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0034"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2022.01.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.03.228"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-007-9295-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07241-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20523"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255537"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281676"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.1171"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-019-0376-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-2-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10396-019-00959-x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.354"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393564"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.12.033"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.03.1081"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1027327"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:07:26Z","timestamp":1764608846000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12,1]]},"published-print":{"date-parts":[[2025,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000548246","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}