{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:53:46Z","timestamp":1760576026723,"version":"build-2065373602"},"reference-count":37,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"abstract":"<jats:p>Introduction: We aimed to investigate malignancy rates in atypia of undetermined significance (AUS) subcategories and their association with cytomorphologic and ultrasonographic features. Methods: A total of 201 thyroid nodules with AUS cytology that underwent surgical resection were analyzed, including 169 AUS-nuclear (AUS-N) and 32 AUS-other (AUS-O) nodules. Cytomorphological and ultrasonographic features, along with the American College of Radiology Thyroid Imaging Reporting and Data System (ACR-TIRADS) and the European Thyroid Imaging Reporting and Data System (EU-TIRADS) classifications, were analyzed to assess the association between malignancy and AUS subcategories. Results: The overall risk of malignancy (ROM) for AUS nodules was 19.4%, with a significantly higher rate observed in the AUS-N subgroup compared to AUS-O (21.9% vs. 6.3%, p = 0.04). A significantly higher ROM was observed in nodules with irregular margin, taller-than-wide shape, microcalcification, hypoechogenicity, and solid composition (OR = 9.63, 5.81, 3.33, 2.14, and 2.07, respectively). A statistically significant difference in ROM was observed across ACR-TIRADS and EU-TIRADS categories within the AUS nodules (p &lt; 0.001 for both) and the AUS-N group (p = 0.001 and &lt;0.001). A marked increase in ROM was observed with nuclear overlapping, pseudoinclusions, and enlargement (OR: 9.16, 4.47 and 2.80, respectively), while oncocytic atypia was associated with a reduced risk (OR: 0.44). In multivariate analysis, nuclear overlapping, pseudoinclusions, and sonographic irregular margins remained as independent predictors of malignancy (OR = 6.97, 6.09, and 5.79, respectively). Conclusion: To our knowledge, this is the first study to demonstrate a significant association between ACR-TIRADS classification and malignancy risk in the AUS-N subcategory. <\/jats:p>","DOI":"10.1159\/000548285","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T16:00:37Z","timestamp":1756828837000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["The Association between Subcategorization, Cytomorphological Features, and Ultrasonographic Characteristics with Surgical Outcomes of Atypia of Undetermined Significance Thyroid Nodules"],"prefix":"10.1159","author":[{"given":"Ahmet Kursat","family":"Soyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysegul Aksoy","family":"Altinboga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokcen 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