{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:50:58Z","timestamp":1782978658585,"version":"3.54.5"},"reference-count":28,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>Introduction: Current definitions of clinical remission (CR) use different tools and thresholds to define good asthma control. Their differential impact on CR rates in severe asthma is poorly understood. Methods: Data from a real-world study in patients with SEA treated with benralizumab (imPROve Asthma, NCT04184284, total number of patients: 244 patients) were analyzed. Four-component CR (4-CR) was defined as no exacerbations, no systemic steroid treatment, stable or normal lung function, and good asthma control, for at least 12 months. The impact of 2 different asthma control measures (Asthma Control Questionnaire [ACQ] and Asthma Control Test [ACT]) with varying thresholds for good asthma control (ACQ: \u22641.5 or \u22640.75, ACT: \u226520 or \u226523) on CR rates was examined. Results: Complete data on all remission criteria were available for 131 patients after 12 months of follow-up, and 85 patients after 24 months of follow-up. After 12 months, 4-CR criteria were fulfilled in 42.7% (ACQ-6 \u22641.5), 36.9% (ACT \u226520), 24.4% (ACQ-6 \u22640.75), and 21.5% (ACT \u226523) of the patients. After 24 months, 4-CR criteria were fulfilled in 39.2% (ACQ-6 \u22641.5), 31.8% (ACT \u226520), 22.8% (ACQ-6 \u22640.75), and 17.6% (ACT \u226523) of the patients. Conclusion: CR is achievable in a substantial proportion of patients with SEA treated with benralizumab in a real-world setting. CR rates are strongly dependent on definitions of asthma control, with almost twice as high CR rates found using the ACQ-6 \u22641.5 criterion as compared with the ACT \u226523 criterion.<\/jats:p>","DOI":"10.1159\/000548349","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:01:31Z","timestamp":1757347291000},"page":"12-21","source":"Crossref","is-referenced-by-count":6,"title":["Benralizumab-Induced Asthma Remission: Impact of Different Tools and Thresholds to Define Good Asthma Control"],"prefix":"10.1159","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-9348","authenticated-orcid":false,"given":"Marek","family":"Lommatzsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Watz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Grund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Plate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Saathoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Korn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00331-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001068"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.103050"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00304-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00415-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00293-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703501"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30344-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30414-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/a-2070-2135"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01521-2023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02539-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14544"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2024.2332351"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13103013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S503048"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14062075"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S495867"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2024.10.009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.05.047"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.08.023"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00490-8"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/cea.70083"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1055\/a-2346-9840"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.011"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.08.012"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1101134"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:01:05Z","timestamp":1769792465000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,30]]},"published-print":{"date-parts":[[2026,2,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000548349","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]}}}