{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:32:53Z","timestamp":1769196773701,"version":"3.49.0"},"reference-count":29,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"abstract":"<jats:p>Introduction: This study investigated the relationship between textbook outcomes of liver surgery (TOLS) and overall survival (OS) in patients who underwent curative-intent resection of GBC. Methods: Patients with GBC who underwent curative-intent resection between 2014 and 2021 were selected from 16 hospitals. Patients were divided into either the TOLS group or the non-TOLS group, according to whether TOLS were observed. Patients who died within 90 days of surgery were excluded prior to the survival analysis. Log-rank test was used to compare the difference in the OS rate between TOLS and non-TOLS groups. Univariate and multivariate analyses were performed using Cox regression analysis to identify factors independently associated with OS. Results: A total of 913 patients were selected, 565 (61.9%) exhibited TOLS. The 5-year OS rate in the TOLS group was significantly higher than that in the non-TOLS group (45.4% vs. 21.9%; p &lt; 0.001). Multivariate Cox regression analysis confirmed TOLS, total bilirubin level &gt;54 \u00b5mol\/mL, carcinoembryonic antigen level &gt;5 \u00b5g\/mL, CA 19-9 level &gt;37 U\/L, poor differentiation, stages T2 and T3\/4 according to the 8th edition AJCC T staging manual, N1 and N2 according to the 8th edition AJCC N staging manual, and adjuvant chemotherapy as independent risk factors that affect OS after curative-intent resection of GBC. Conclusion: Among patients who undergo curative-intent resection of GBC, approximately 61.9% experience TOLS. TOLS are not only the optimal short-term outcome but also associated with long-term survival.<\/jats:p>","DOI":"10.1159\/000548351","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:00:43Z","timestamp":1757606443000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Association between Textbook Outcomes of Liver Surgery and Overall Survival in Gallbladder Cancer Patients Treated with Curative-Intent Resection: A Multicenter Study"],"prefix":"10.1159","author":[{"given":"Zi-Mu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ying","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Su","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Yu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Guo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Xue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Long","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Can","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery (EGCDS)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00398-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000510"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i9.948"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0035"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v15.i6.1036"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1850-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004808"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-02015-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005668"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.12.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/625093"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-021-05211-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.849053"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106234"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.10.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.2064"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06255-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000244"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11721-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000250"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199211000-00007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1104810"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/cai2.45"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30915-X"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02038-4"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000046"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00082-2"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00727-4"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:01:04Z","timestamp":1761235264000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":29,"URL":"https:\/\/doi.org\/10.1159\/000548351","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30095686","asserted-by":"subject"}]},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]}}}