{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:43:48Z","timestamp":1777308228418,"version":"3.51.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerontology"],"abstract":"<jats:p>Introduction: This study aimed to evaluate the effects of a 12-week dual-task resistance training (RT) program on inflammatory and metabolic biomarkers in institutionalized older adults and assess the impact of detraining. Methods: The study followed a crossover experimental design. Participants were 11 older adults (mean age: 81.9 \u00b1 3.0 years), who completed baseline (week 1), post-control (weeks 14\u201315), post-training (week 28), and post-detraining (week 42) assessments over 42 weeks. Immunometabolic markers, including interleukin (IL)-10, IL-18, IL-17, transforming growth factor-beta, sestrin-2, klotho, adiponectin, leptin, and irisin, were measured using enzyme-linked immunosorbent assay kits. A 12-week dual-task RT program (weeks 16\u201327) was carried out progressively, incorporating cognitive tasks during lower limb exercises. Cognitive complexity increased monthly, and detraining followed in weeks 29\u201341. Results: Results demonstrated a significant post-training increase in IL-10 (p = 0.011) and a decrease in IL-18 (p &lt; 0.001), indicating improved inflammatory status. Metabolic markers such as sestrin-2 (p = 0.016), klotho (p &lt; 0.001), adiponectin (p = 0.019), and irisin (p = 0.009) also increased post training. Notably, klotho and irisin levels remained elevated post detraining, suggesting sustained benefits. Conclusion: Dual-task RT enhanced inflammatory and metabolic profiles, partially retaining benefits after detraining. This intervention presents a viable strategy to mitigate aging-related systemic health decline in vulnerable populations.<\/jats:p>","DOI":"10.1159\/000548386","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T17:00:50Z","timestamp":1770310850000},"page":"299-305","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Dual-Task Resistance Training and Detraining on Immunometabolic Markers in Institutionalized Older Adults"],"prefix":"10.1159","volume":"72","author":[{"given":"Erivaldo","family":"Machado Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio Jos\u00e9","family":"Coelho-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana","family":"Passos Milhomem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Moura 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