{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:50:47Z","timestamp":1765371047969,"version":"3.46.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Cetuximab is an effective therapy for unresectable locoregionally advanced head and neck cancer, but for patients with end-stage renal disease (ESRD), clinical trials seldom provide evidence for the efficacy and safety of cetuximab. Case Presentation: We report this case of 46-year-old male patient with stage IVa tongue squamous cell carcinoma who is on maintenance hemodialysis for diabetic nephropathy. He tolerated the therapy well and had a stable disease of the carcinoma. We determined cetuximab concentration and showed that pharmacokinetics of cetuximab in this ESRD patient was similar to healthy subjects. Conclusion: Cetuximab can be used safely and effectively in head and neck cancer patients with ESRD, and we have provided an example of pharmacokinetics of cetuximab in renal failure patient. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000548464","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:01:10Z","timestamp":1760976070000},"page":"1510-1516","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Blood Concentrations of Cetuximab in a Hemodialysis Patient with Tongue Squamous Cell Carcinoma: A Case Report"],"prefix":"10.1159","volume":"18","author":[{"given":"Ting-Ting","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Jie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Piao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Hai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.09.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2025.0007"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.504"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.11.824"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.147"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70311-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.4.904"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.13.3234"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1542"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.7674"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000112828"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000025"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21057"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0705"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:13:07Z","timestamp":1765357987000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000548464","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2025,10,16]]}}}