{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:05:03Z","timestamp":1767719103575,"version":"3.48.0"},"reference-count":29,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>Introduction: The significance of autografts\u2019 contamination by clonal plasma cells on clinical outcome in newly diagnosed multiple myeloma (NDMM) remains controversial. Methods: We retrospectively reviewed the clinical and laboratory data of NDMM patients who underwent autologous stem cell transplantation (ASCT) and had received graft minimal residual disease (gMRD) examination by multi-color flow cytometry. Results: From January 2011 to December 2022, 250 NDMM patients with complete cytogenetic information, gMRD information, and who received ASCT as consolidation were enrolled. Multi-flow cytometry can achieve a median detection sensitivity of 0.004%, and gMRD positivity was 12.4% at a median level of 0.0160% (interquartile range, 0.0049%, 0.05394%). Its presence was correlated with response to induction treatment, with percentages of 2.65%, 12.94%, 28.89%, and 57.14% of patients achieving complete response, very good partial response, partial response, and minimal response\/stable disease, respectively. gMRD (+) patients had a higher risk of not achieving bone marrow MRD negativity post-ASCT. After a median follow-up of 33.5 months for the whole cohort, patients in the gMRD (+) group had significantly worse progression-free survival (PFS) than those in the gMRD (\u2212) group did (34.8 vs. 65.0 months, p = 0.001). Multivariable analysis revealed that gMRD (\u2212) was independently predictive of better PFS (hazard ratio 0.464, 95% confidence interval: 0.274\u20130.785, p = 0.004). We found the significance of gMRD on PFS was in high-risk subgroups and in patients who achieved \u2264 partial response prior to ASCT. Conclusions: In conclusion, gMRD (+) was an independent risk factor for inferior progression-free survival, with the impact primarily affecting high-risk groups and patients who achieved \u2264 partial response before ASCT.<\/jats:p>","DOI":"10.1159\/000548496","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T17:01:04Z","timestamp":1763485264000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Minimal Clonal Plasma Cell Contamination of Peripheral Stem Cell Grafts Has an Adverse Prognostic Impact in Patients with Multiple Myeloma Undergoing Autologous Transplantation"],"prefix":"10.1159","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelin","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0134"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.10.014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.21-0176"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.74"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.633"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.800711"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0635-y"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164047"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00842-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2022.01.013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000002159"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21228"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/BS9.0000000000000190"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253-2727.2017.04.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21228"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21754"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2123229"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14391"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007625"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022859"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05427-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.08.020"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.142"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.130"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.04.011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01133.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.17.3771"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2023.104138"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01365"}],"container-title":["Acta 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