{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:35:01Z","timestamp":1791923701684,"version":"4.3.4"},"reference-count":59,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: Gut microbiota plays a critical role in health and may contribute to post-COVID manifestations, as alterations in microbial communities have been observed in affected individuals. This study aimed to identify microbial and biochemical signatures in post-COVID individuals after an extended period following acute infection. Methods: A total of 90 subjects were recruited, divided into three equal groups: post-COVID, fully recovered individuals, and healthy controls. The post-COVID group was further stratified by symptom duration and severity. Fecal microbiota was analyzed using 16S rRNA gene sequencing (V&lt;sub&gt;3&lt;\/sub&gt;-V&lt;sub&gt;4&lt;\/sub&gt; region), with differential abundance assessed through LEfSE. Biochemical parameters were measured using the Mindray BS800 system. Spearman\u2019s correlation was applied to explore associations between taxonomic groups and biochemical markers. Results: Several microbial taxa exhibited positive correlations with high-density lipoprotein (HDL) levels and negative associations with non-HDL lipid parameters and CRP, highlighting their potential role in health. Individuals with a history of COVID-19 showed a significantly lower relative abundance of Phascolarctobacterium, Slackia, Enterorhabdus, and Senegalimassilia (p &lt; 0.05, LDA &gt;2) compared to healthy controls. In participants with post-COVID symptoms, Eggerthella was significantly enriched, with Holdemania, Gemella, and two uncultured Lachnospiraceae showing a trend toward higher abundance. Severe post-COVID cases showed higher Parasutterella abundance, while long-lasting symptoms (&gt;1 year) were associated with Dialister enrichment and Phascolarctobacterium depletion compared to controls and fully recovered individuals. Conclusion: Gut microbiota alterations were observed in post-COVID individuals even after a prolonged period following acute infection, suggesting a potential link between microbial imbalance and lingering symptoms, though causality cannot be confirmed.<\/jats:p>","DOI":"10.1159\/000548507","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:01:07Z","timestamp":1759334467000},"page":"731-746","source":"Crossref","is-referenced-by-count":3,"title":["Gut Microbiota as a Key Player in Health and Disease with a Focus on Long-Term Alterations in 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