{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T22:12:47Z","timestamp":1772143967691,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>&lt;p&gt;Introduction: Nicolau syndrome (NS) is a rare complication following intramuscular (IM), intra-articular, or subcutaneous injections, marked by severe localized pain, skin discoloration, and tissue necrosis. Treatments focus on halting causative agents, pain control, and preventing secondary infections. Here we describe a case of NS due to the use of penicillin G benzathine for syphilis. Case Presentation: A 39-year-old male presented with a painful rash on his left buttock 3 min after IM injection of penicillin G benzathine for the treatment of syphilis. The patient, with a history of type 2 diabetes, experienced significant complications including rhabdomyolysis and liver dysfunction. After the treatment of corticosteroids, anticoagulation, fluid resuscitation, and alkalinizing the urine, the patient recovered well. Conclusion: NS may result from accidental arterial injection (causing vascular occlusion) or hypersensitivity reactions to medications. We reported the clinical course of a case of NS and highlight the need for proper injection technique, early intervention, and multidisciplinary care to manage NS and its complications. &lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/000548557","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:00:58Z","timestamp":1762448458000},"page":"613-619","source":"Crossref","is-referenced-by-count":3,"title":["Nicolau Syndrome following Benzathine Benzylpenicillin Injection in a Patient with Syphilis and Type 2 Diabetes: A Case Report"],"prefix":"10.1159","volume":"17","author":[{"given":"Yuyan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2020.07.029"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9082158"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103365"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52044"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2024.02.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/1556-4029.13126"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/jiaps.jiaps_171_23"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620948768"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00980"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.28920\/dhm52.2.149-153"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2022.06.010"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:10:39Z","timestamp":1765357839000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000548557","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30530048","asserted-by":"subject"}]},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]}}}