{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:02:53Z","timestamp":1763398973816,"version":"3.45.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"abstract":"<jats:p>Background: Traditional Chinese medicine (TCM) is widely used as an adjuvant therapy for advanced gastric cancer (AGC), yet its underlying mechanisms and targets remain inadequately characterized. Methods: This study integrated meta-analysis and network pharmacology to evaluate the therapeutic effects of TCM, identify core-effective prescriptions (CEPs), and predict potential molecular targets. Results: Seventeen studies comparing TCM combined with chemotherapy versus chemotherapy alone for AGC were identified through a search of seven databases. Meta-analysis showed that TCM significantly improved overall survival (OS) (hazard ratio: 1.65, 95% confidence interval: 1.23\u20132.22, p &lt; 0.001, I2 = 0%). CEPs and their chemical constituents were identified. A component-target (C-T) network was constructed, revealing the top 10 core genes were TP53, AKT1, CASP3, MYC, IL6, ESR1, EGFR, TNF, PTEN, and HIF1A. Conclusion: This meta-analysis demonstrates that TCM combined with chemotherapy improves OS in AGC patients more effectively than chemotherapy alone. Network pharmacology offered complementary mechanistic insights, laying a foundation for future experimental research.<\/jats:p>","DOI":"10.1159\/000548562","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T16:00:59Z","timestamp":1758556859000},"page":"402-418","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of Traditional Chinese Medicine in Advanced Gastric Cancer: Insights from Meta-Analysis and Network Pharmacology"],"prefix":"10.1159","volume":"32","author":[{"given":"Zhenzheng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leitao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieru","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2478\/jtim-2023-0103"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153322"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.800571"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-016-2499-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118277"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118812"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02149-x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117999"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.632168"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1431381"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/15347354241229414"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1168226"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7044"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20210902.701"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:01:11Z","timestamp":1763398871000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11,17]]},"published-print":{"date-parts":[[2025,11,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000548562","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30163729","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"type":"print","value":"2504-2092"},{"type":"electronic","value":"2504-2106"}],"subject":[],"published":{"date-parts":[[2025,9,22]]}}}