{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:00:51Z","timestamp":1771610451169,"version":"3.50.1"},"reference-count":41,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: Green tea polyphenols (GTPs) and aspirin were demonstrated to be novel candidates for cancer chemoprevention. This study aimed to investigate effects of GTPs and aspirin on esophageal diseases. Methods: This non-randomized prospective cohort study recruited participants from October 2010 to September 2011, who self-reported long-term GTPs intake, aspirin intake, and no medicine use in a questionnaire and underwent gastroscopy. Regression was defined as any reversal of process from normal epithelium to esophageal high-grade intraepithelial neoplasia. The primary outcome was regression rates after a 1-year follow-up. Results: A total of 159, 151, 160 participants self-reported GTPs intake, aspirin intake, and no medication, respectively. After 1 year, 78, 81, and 83 participants received follow-up endoscopy in GTPs, aspirin, and control groups, respectively. There was no statistically significant difference in baseline pathology between the final cohort and lost to follow-up group. The average age of participants was 50.11 \u00b1 5.62 years old, consisting of 42 females and 200 males. The regression rates of esophageal precursor diseases were 68%, 55%, and 48% in GTPs, aspirin, and control groups, respectively (p = 0.036). Analyzing esophagitis subgroup, the regression rate of GTPs group (43\/69, 62%) was significantly higher than aspirin group (32\/67, 48%) and control group (27\/70, 39%) (p = 0.019). One person experienced nausea for GTPs (1\/159) and one person experienced gastrointestinal bleeding in the aspirin group (1\/151). Conclusions: GTPs, rather than aspirin, were associated with esophagitis remission compared with the control group. The benefits of GTPs on esophageal precursor diseases make it a promising health supplement.<\/jats:p>","DOI":"10.1159\/000548588","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:01:18Z","timestamp":1760371278000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Green Tea Polyphenols Ameliorate Esophagitis rather than Aspirin in a Non-Randomized Prospective Cohort Study"],"prefix":"10.1159","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-9584","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2674-6022","authenticated-orcid":false,"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-2758","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengtao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-4397","authenticated-orcid":false,"given":"Shutian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6346-2024","authenticated-orcid":false,"given":"Jie","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2019.05.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000640"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.47415"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b06146"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-009-0068-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1231168"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2188\/jea.16.185"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24142"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2000"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32220"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.022"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X16657985"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.32072"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.10.044"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103525"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001939"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac087"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35254"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01890-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2012.680205"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020294"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050954"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051744"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-287"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.02.002"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.031419"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14646-z"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-022-00308-y"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-01682-z"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34458"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.4"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.083"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7005328"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3137"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2852"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.012"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1803955"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804988"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:00:58Z","timestamp":1771606858000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,20]]},"published-print":{"date-parts":[[2026,2,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000548588","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30343645","asserted-by":"subject"}]},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]}}}