{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:16:02Z","timestamp":1783041362225,"version":"3.54.6"},"reference-count":31,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"abstract":"<jats:p>Introduction: Hyperthyroidism-related epithelial hyperplasia is seldomly listed as a pitfall in thyroid cytology. Therefore, we focused on the cytomorphological characteristics of epithelial hyperplasia and compared these features with papillary thyroid carcinoma (PTC). Methods: Study group consisted of 76 patients (133 FNA specimens) histologically diagnosed with hyperthyroidism-related epithelial hyperplasia without a concomitant malignancy. The control group contained 21 histologically verified FNAs of PTCs. A total of 48 cytomorphological features were quantitatively evaluated. Results: Statistically significant differences between the study groups were discovered on the architectural, cellular, and nuclear levels. Nuclear features varied most: nuclear elongation, grooves, irregular nuclear membrane, pseudoinclusions, the presence of nucleoli or small eccentric nucleoli were clearly more common in PTC group. Conclusion: Fine-needle aspiration referrals with clinical data and thyroid function test results can facilitate the interpretation of cytomorphological features and reduce the use of undetermined categories in cases of hyperthyroidism-related epithelial hyperplasia.<\/jats:p>","DOI":"10.1159\/000548613","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:01:03Z","timestamp":1760025663000},"page":"151-159","source":"Crossref","is-referenced-by-count":1,"title":["Hyperthyroidism-Related Epithelial Hyperplasia as a Potential Pitfall of Thyroid Cytology: Institutional Cytomorphological Analysis of Histologically Verified Cases"],"prefix":"10.1159","volume":"70","author":[{"given":"Eliisa Eveliina","family":"Viljanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotta","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-4113","authenticated-orcid":false,"given":"David","family":"Kalfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Ludv\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22309"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12575"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000535907"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpz33mvmgzkewu"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1979.tb06043.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1972.tb00282.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.565"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000464094"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20075"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.112657"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2023.04.006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12840"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000333979"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24319"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2020-0023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.18231\/j.ijpo.2020.074"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.5430\/crcp.v1n1p1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1469"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030708"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2024.03.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01415.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-38-6-976"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299741"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200010263431707"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1397-1"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-021-09679-w"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2014.08.006"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.10.003"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12513"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000514906"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.21037\/gs-20-688"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:02:19Z","timestamp":1775145739000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,2]]},"published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000548613","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"value":"0001-5547","type":"print"},{"value":"1938-2650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}