{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:59:40Z","timestamp":1776099580781,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"abstract":"<jats:p>Introduction: Acquired hemophilia A (AHA) manifests as a significant deficiency in coagulation factor VIII (FVIII) activity caused by the development of autoantibodies against FVIII and results in severe bleeding symptoms that can be life-threatening. Therefore, patients with AHA often require blood transfusions. Emicizumab, a bispecific monoclonal antibody that replaces the function of activated FVIII, has been more widely used to treat AHA. Case Presentation: We report a 70-year-old male Jehovah\u2019s Witness with AHA who refused blood transfusions despite experiencing severe bleeding in the left biceps muscle; anemia had progressed by 3 g\/dL (hemoglobin level) in just 2 days. Since the use of coagulation factor products had been approved in writing, we administered a single-dose mixture of activated factor VIIa\/X (Byclot\u00ae) and promptly achieved hemostasis. Subsequently, regular administration of emicizumab was effective in preventing rebleeding and successfully avoiding blood transfusions. Conclusion: For Jehovah\u2019s Witnesses with AHA, the administration of emicizumab can be considered a highly valuable treatment.<\/jats:p>","DOI":"10.1159\/000548759","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:05:21Z","timestamp":1759421121000},"page":"112-116","source":"Crossref","is-referenced-by-count":0,"title":["A Jehovah\u2019s Witness with Acquired Hemophilia A Who Successfully Avoided Blood Transfusions by Receiving Emicizumab"],"prefix":"10.1159","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-9475","authenticated-orcid":false,"given":"Makoto","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yasumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ieko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Kanaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh","family":"Izumiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-029850"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408930"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-0704(18)30627-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16284"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-409185"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002977"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02837-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12992"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-244928"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057479"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803550"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30054-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006315"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.10.004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/a-2384-3585"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00280-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.06.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02259.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/road026"}],"container-title":["Transfusion Medicine and Hemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000548759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T16:01:04Z","timestamp":1776096064000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000548759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4,13]]},"published-print":{"date-parts":[[2026,4,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000548759","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.30256441","asserted-by":"subject"}]},"ISSN":["1660-3796","1660-3818"],"issn-type":[{"value":"1660-3796","type":"print"},{"value":"1660-3818","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]}}}